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• W2010751561 abstract "Fabrication of nonlinear elastic materials that resemble biological tissues remains a challenge in biomaterials research. Here, a new fabrication protocol to produce elastomeric fibrous scaffolds was established, using the core/shell electrospinning technique. A prepolymer of poly(xylitol sebacate) with a 2:5 mol ratio of xylitol:sebacic acid (PXS2:5) was first formulated, then co-electrospun with polyvinyl alcohol (PVA – 95,000 Mw). After cross-linking of core polymer PXS2:5, the PVA shells were rinsed off in water, leaving a porous elastomeric network of PXS2:5 fibres. Under aqueous conditions, the PXS2:5 fibrous scaffolds exhibited stable, nonlinear J-shaped stress–strain curves, with large average rupture elongation (76%) and Young׳s modulus (~1.0 MPa), which were in the range of muscle tissue. Rupture elongation of PXS2:5 was also much higher when electrospun, compared to 2D solid sheets (45%). In direct contact with cell monolayers under physiological conditions, PXS2:5 scaffolds were as biocompatible as those made of poly-l-lactic acid (PLLA), with improvements over culture medium alone. In conclusion, the newly developed porous PXS2:5 scaffolds show tissue-like mechanical properties and excellent biocompatibility, making them very promising for bioengineering of soft tissues and organs." @default.
• W2010751561 created "2016-06-24" @default.
• W2010751561 creator A5042472699 @default.
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• W2010751561 date "2014-12-01" @default.
• W2010751561 modified "2023-10-16" @default.
• W2010751561 title "Novel elastomeric fibrous networks produced from poly(xylitol sebacate) 2:5 by core/shell electrospinning: Fabrication and mechanical properties" @default.
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• W2010751561 doi "https://doi.org/10.1016/j.jmbbm.2014.08.027" @default.
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