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• W2010757788 abstract "In order to better understand the role of prolactin (PRL) and luteinizing hormone (LH) on progesterone biosynthesis in the ovary, we have investigated the time course (1–9 days) of the effect of PRL and human chorionic gonadotropin (hCG) on ovarian 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) expression in the hypophysectomized rat. As evaluated by quantitative in situ hybridization using a 35S labelled type I 3β-HSD cDNA probe, the administration of hCG for 2, 3 and 9 days induced increases of 63%, 145% and 146% above control, respectively, in 3β-HSD mRNA levels in ovarian interstitial cells. The absence of apparent effect of the gonadotropin in other ovarian cell types could explain the small modulation of ovarian 3β-HSD protein content and enzymatic activity observed in total ovarian tissue. On the other hand, treatment with PRL caused a rapid decrease in 3β-HSD mRNA levels in corpus luteum by 23%, 63%, 76% and 78% (P < 0.01) following 1, 2, 5 and 9 days of treatment, respectively. The short-term inhibitory effect of PRL was also observed on ovarian immunoreactive 3β-HSD protein, as measured by Western blot analysis, and on 3β-HSD activity measured by the conversion of [14C]dehydroepiandrosterone into [14C]androstenedione. The inhibitory effect of PRL on 3β-HSD expression and activity is correlated with a progressive decrease in serum progesterone concentration from a pretreatment value of 4.8 nM to levels below the limit of detection (< 0.13 nM) after 7–9 days of treatment with PRL, while serum pregnenolone levels were decreased by only approximately 55% after 9 days. The present findings indicate that the inhibition of 3β-HSD gene expression and activity in corpora lutea occurrs early in the luteolytic process induced by PRL and could well play an important role in this process." @default.
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• W2010757788 date "1994-02-01" @default.
• W2010757788 modified "2023-09-25" @default.
• W2010757788 title "Rapid modulation of ovarian 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase gene expression by prolactin and human chorionic gonadotropin in the hypophysectomized rat" @default.
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• W2010757788 doi "https://doi.org/10.1016/0303-7207(94)90147-3" @default.
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