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• W2010763866 abstract "The cyclic neuropeptide, somatostatin, is widely expressed in mammalian brain and modulates hormone secretion and neurotransmission. The long-term potentiation (LTP) at Schaffer collateral synapses onto hippocampal CA1 pyramidal neurons has been intensively studied as a cellular model of learning and memory. The apical (stratum radiatum) and basal dendrites (stratum oriens) of CA1 pyramidal neurons differ in LTP induction and maintenance. Here the role of somatostatin in the modulation of LTP was investigated in rat hippocampus. Our results show that somatostatin enhances LTP in apical and basal dendrites. However, the activation conditions of the somatostatin system are different in these two compartments." @default.
• W2010763866 created "2016-06-24" @default.
• W2010763866 creator A5009741300 @default.
• W2010763866 creator A5053661149 @default.
• W2010763866 date "2014-02-01" @default.
• W2010763866 modified "2023-09-23" @default.
• W2010763866 title "Somatostatin modulates LTP in hippocampal CA1 pyramidal neurons: Differential activation conditions in apical and basal dendrites" @default.
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• W2010763866 doi "https://doi.org/10.1016/j.neulet.2013.12.025" @default.
• W2010763866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24384127" @default.
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