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- W2010796543 abstract "<h3>To the Editor.—</h3> We read with interest the long-awaited update on the recommendations for the prevention of bacterial endocarditis by the American Heart Association.<sup>1</sup>We were somewhat perplexed by the recommendation of the committee to use erythromycin ethylsuccinate and erythromycin stearate as opposed to the traditional erythromycin base. The authors recommended these products because of more rapid and reliable absorption than other erythromycin formulations, resulting in higher and more sustained serum levels. We would like to comment on the rates of absorption of the various products, interpretation of the serum levels, and, finally, the dosage of the ethylsuccinate ester. The stearate salt is hydrolyzed in the duodenum and then absorbed as the active free base. The biologically inactive erythromycin ethylsuccinate ester is absorbed intact and then hydrolyzed in the bloodstream to the active free base.<sup>2</sup>While it is true that the rate of absorp" @default.
- W2010796543 created "2016-06-24" @default.
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- W2010796543 date "1991-04-03" @default.
- W2010796543 modified "2023-09-27" @default.
- W2010796543 title "Prevention of Bacterial Endocarditis" @default.
- W2010796543 cites W2135554816 @default.
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- W2010796543 doi "https://doi.org/10.1001/jama.1991.03460130078019" @default.
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