Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010804634> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2010804634 endingPage "744" @default.
- W2010804634 startingPage "733" @default.
- W2010804634 abstract "The macrodiolide antibiotic (+)-colletodiol (7, Scheme 1) was synthesised. The configuration was thus proven to be (6R,11R,12R,14R). – Key intermediates (Schemes 9 and 10) are the two hydoxy acids 43 and 64, which were prepared from dimethyl (S,S)-tartrate in 20% overall yield (12 steps) and from (R)-3-hydroxybutanoate in 57% overall yield (6 steps), respectively. The two hydroxy acids were cyclised to give, after deprotection, the title compound. – Our investigations led to the production of a large number of chiral building blocks, many of them in different stereoisomeric forms. Totalsynthese von (+)-Colletodiol aus (S,S)-Weinsäure und (R)-3-Hydroxybuttersäure Das Makrodiolid-Antibiotikum (+)-Colletodiol (7, Schema 1) wurde synthetisiert. Die (6R,11R,12R,14R)-Konfiguration wurde damit bewiesen. – Schlüsselprodukte (Schema 9 und 10) sind die zwei Hydroxycarbonsäuren 43 und 64, die in 20% Gesamtausbeute in 12 Stufen aus (S,S)-Weinsäure-dimethylester, respektive in 57% Gesamtausbeute in 6 Stufen aus (R)-3-Hydroxybuttersäure-methylester hergestellt wurden. Die zwei Hydroxysäuren wurden cyclisiert und ergaben, nach Abspaltung der Schutzgruppen, die Titelverbindung. – Auf dem Weg zu diesem Zielmolekül wurde eine große Anzahl von chiralen Synthesebausteinen hergestellt, viele von ihnen in mehreren stereoisomeren Formen." @default.
- W2010804634 created "2016-06-24" @default.
- W2010804634 creator A5004963877 @default.
- W2010804634 creator A5042236728 @default.
- W2010804634 creator A5050116539 @default.
- W2010804634 date "1987-09-14" @default.
- W2010804634 modified "2023-10-09" @default.
- W2010804634 title "Total Synthesis of (+)-Colletodiol from (S,S)-Tartrate and (R)-3-Hydroxybutanoate" @default.
- W2010804634 cites W1584969691 @default.
- W2010804634 cites W1979554636 @default.
- W2010804634 cites W1985804456 @default.
- W2010804634 cites W1988317797 @default.
- W2010804634 cites W1992688100 @default.
- W2010804634 cites W2006100704 @default.
- W2010804634 cites W2009534274 @default.
- W2010804634 cites W2012578875 @default.
- W2010804634 cites W2015606382 @default.
- W2010804634 cites W2022412731 @default.
- W2010804634 cites W2025135596 @default.
- W2010804634 cites W2026614656 @default.
- W2010804634 cites W2027887585 @default.
- W2010804634 cites W2044783547 @default.
- W2010804634 cites W2049924436 @default.
- W2010804634 cites W2057752461 @default.
- W2010804634 cites W2062157351 @default.
- W2010804634 cites W2070531418 @default.
- W2010804634 cites W2075644388 @default.
- W2010804634 cites W2077962584 @default.
- W2010804634 cites W2078889581 @default.
- W2010804634 cites W2081373871 @default.
- W2010804634 cites W2116583081 @default.
- W2010804634 cites W2153620830 @default.
- W2010804634 cites W2313702279 @default.
- W2010804634 cites W2412544214 @default.
- W2010804634 cites W2950092857 @default.
- W2010804634 cites W3004819063 @default.
- W2010804634 cites W3005220366 @default.
- W2010804634 doi "https://doi.org/10.1002/jlac.198719870821" @default.
- W2010804634 hasPublicationYear "1987" @default.
- W2010804634 type Work @default.
- W2010804634 sameAs 2010804634 @default.
- W2010804634 citedByCount "26" @default.
- W2010804634 countsByYear W20108046342013 @default.
- W2010804634 countsByYear W20108046342017 @default.
- W2010804634 countsByYear W20108046342018 @default.
- W2010804634 countsByYear W20108046342022 @default.
- W2010804634 crossrefType "journal-article" @default.
- W2010804634 hasAuthorship W2010804634A5004963877 @default.
- W2010804634 hasAuthorship W2010804634A5042236728 @default.
- W2010804634 hasAuthorship W2010804634A5050116539 @default.
- W2010804634 hasConcept C121332964 @default.
- W2010804634 hasConcept C134121241 @default.
- W2010804634 hasConcept C178790620 @default.
- W2010804634 hasConcept C185592680 @default.
- W2010804634 hasConcept C2777699559 @default.
- W2010804634 hasConcept C35753019 @default.
- W2010804634 hasConcept C71240020 @default.
- W2010804634 hasConcept C97355855 @default.
- W2010804634 hasConceptScore W2010804634C121332964 @default.
- W2010804634 hasConceptScore W2010804634C134121241 @default.
- W2010804634 hasConceptScore W2010804634C178790620 @default.
- W2010804634 hasConceptScore W2010804634C185592680 @default.
- W2010804634 hasConceptScore W2010804634C2777699559 @default.
- W2010804634 hasConceptScore W2010804634C35753019 @default.
- W2010804634 hasConceptScore W2010804634C71240020 @default.
- W2010804634 hasConceptScore W2010804634C97355855 @default.
- W2010804634 hasIssue "9" @default.
- W2010804634 hasLocation W20108046341 @default.
- W2010804634 hasOpenAccess W2010804634 @default.
- W2010804634 hasPrimaryLocation W20108046341 @default.
- W2010804634 hasRelatedWork W1531601525 @default.
- W2010804634 hasRelatedWork W1975252703 @default.
- W2010804634 hasRelatedWork W2319480705 @default.
- W2010804634 hasRelatedWork W2384464875 @default.
- W2010804634 hasRelatedWork W2606230654 @default.
- W2010804634 hasRelatedWork W2607424097 @default.
- W2010804634 hasRelatedWork W2748952813 @default.
- W2010804634 hasRelatedWork W2899084033 @default.
- W2010804634 hasRelatedWork W2948807893 @default.
- W2010804634 hasRelatedWork W2778153218 @default.
- W2010804634 hasVolume "1987" @default.
- W2010804634 isParatext "false" @default.
- W2010804634 isRetracted "false" @default.
- W2010804634 magId "2010804634" @default.
- W2010804634 workType "article" @default.