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- W2010805599 abstract "We have previously isolated a novel Ras GTPase-activating protein (Ras GAP), Gap1m, from rat brain. Gap1m is considered to be a negative regulator of the Ras signaling pathways, like other Ras GAPs, neurofibromin, which is a gene product of the neurofibromatosis type I gene, and p120GAP. In this study we have isolated a human cDNA of this Gap and mapped the gene. The gene encodes a protein of 853 amino acids that shows 89% sequence identity to rat Gap1m. The human gene was mapped to chromosome 3 by PCR analysis on a panel of human-mouse hybrid cells. FISH analysis refined the location of the gene further to 3q22-q23." @default.
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- W2010805599 date "1996-08-01" @default.
- W2010805599 modified "2023-10-02" @default.
- W2010805599 title "cDNA Cloning and Chromosomal Mapping of a Novel Human GAP (GAP1M), a GTPase-Activating Protein of Ras" @default.
- W2010805599 doi "https://doi.org/10.1006/geno.1996.0412" @default.
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