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- W2010818766 abstract "Mitochondrial mutations, an important cause of incurable human neuromuscular diseases, are mostly heteroplasmic: mutated mitochondrial DNA is present in cells simultaneously with wild-type genomes, the pathogenic threshold being generally >70% of mutant mtDNA. We studied whether heteroplasmy level could be decreased by specifically designed oligoribonucleotides, targeted into mitochondria by the pathway delivering RNA molecules in vivo. Using mitochondrially imported RNAs as vectors, we demonstrated that oligoribonucleotides complementary to mutant mtDNA region can specifically reduce the proportion of mtDNA bearing a large deletion associated with the Kearns Sayre Syndrome in cultured transmitochondrial cybrid cells. These findings may be relevant to developing of a new tool for therapy of mtDNA associated diseases." @default.
- W2010818766 created "2016-06-24" @default.
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- W2010818766 date "2012-10-18" @default.
- W2010818766 modified "2023-10-09" @default.
- W2010818766 title "Mitochondrial targeting of recombinant RNAs modulates the level of a heteroplasmic mutation in human mitochondrial DNA associated with Kearns Sayre Syndrome" @default.
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- W2010818766 doi "https://doi.org/10.1093/nar/gks965" @default.
- W2010818766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3592399" @default.
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