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• W2010848252 abstract "Epidermal growth factor receptor (EGFR) that has been over-expressed in many different types of cancers has become logical targets for both diagnosis and therapy. Herein, we report an electrochemical peptide-based biosensor for the detection of EGFR, in which ferrocene moiety modified peptide ligands that are specific to EGFR were immobilized on gold electrode through Au–S interaction. Upon the binding of peptide ligands with EGFR, complex formation changes occurred on the electrode surface, which resulted in current increase. The amplitude of the current increase displayed a linear relationship with logarithm of the EGFR concentrations in the range of 1.0 × 10−6–1.0 × 10−10 g L−1, with a detection limit of 3.7 × 10−11 g L−1. The proposed method has been applied for determination of EGFR in diluted human serum samples with satisfied results." @default.
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• W2010848252 date "2013-10-01" @default.
• W2010848252 modified "2023-10-18" @default.
• W2010848252 title "Electrochemical biosensor for epidermal growth factor receptor detection with peptide ligand" @default.
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• W2010848252 doi "https://doi.org/10.1016/j.electacta.2013.07.151" @default.
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