FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010849649> ?p ?o ?g. }

• W2010849649 endingPage "306" @default.
• W2010849649 startingPage "283" @default.
• W2010849649 abstract "This work describes a mathematical model of growth based on the kinetics of the cell cycle. A traditional model of the cell cycle has been used, with the addition of a resting (G0) state from which cells could reenter the reproductive cycle. The model assumes that a growth regulatory substance regulates the transition of cells to and from the resting state. Other transitions between the phases of the cycle were modeled as a first order process. Cell loss is an important feature of growth kinetics, and has been represented by a general but tractable mathematical form. The resulting model forms a system of ordinary nonlinear differential equations. Analytic methods are employed first in the study of this system. Simplifying assumptions regarding cell loss give rise to special cases for which equilibrium solutions can be found. One special case, which assumes first order loss from all cell cycle phases at equal rates, is presented here. For small time values, approximations corresponding to exponential growth were developed. The equations describing an intrinsic growth rate were derived. Simulation methods were used to further characterize the behavior of this model. Parameter values were chosen based on animal tumor cell cycle kinetic data, resulting in a set of 45 model simulations. Several tumor treatment protocols were simulated which illustrated the importance of the intrinsic growth rate and cell loss concepts. Although the qualitative behavior regarding absolute and relative growth is reasonable, this model awaits data for model fitting, parameter estimation, or revision of the equations." @default.
• W2010849649 created "2016-06-24" @default.
• W2010849649 creator A5012713608 @default.
• W2010849649 creator A5031680484 @default.
• W2010849649 creator A5087391729 @default.
• W2010849649 date "1983-10-01" @default.
• W2010849649 modified "2023-09-28" @default.
• W2010849649 title "A model of tumor growth based on cell cycle kinetics" @default.
• W2010849649 cites W144073452 @default.
• W2010849649 cites W1966196585 @default.
• W2010849649 cites W1977521575 @default.
• W2010849649 cites W1979540178 @default.
• W2010849649 cites W1979704006 @default.
• W2010849649 cites W1987210594 @default.
• W2010849649 cites W1988720903 @default.
• W2010849649 cites W2003837661 @default.
• W2010849649 cites W2009276987 @default.
• W2010849649 cites W2013968942 @default.
• W2010849649 cites W2015165061 @default.
• W2010849649 cites W2016734648 @default.
• W2010849649 cites W2033268422 @default.
• W2010849649 cites W2046872475 @default.
• W2010849649 cites W2047001693 @default.
• W2010849649 cites W2049364601 @default.
• W2010849649 cites W2062707603 @default.
• W2010849649 cites W2086757147 @default.
• W2010849649 cites W2131826223 @default.
• W2010849649 cites W2132504853 @default.
• W2010849649 cites W2135446927 @default.
• W2010849649 cites W2146202672 @default.
• W2010849649 cites W2186323258 @default.
• W2010849649 cites W2281777687 @default.
• W2010849649 cites W82631053 @default.
• W2010849649 doi "https://doi.org/10.1016/0025-5564(83)90094-9" @default.
• W2010849649 hasPublicationYear "1983" @default.
• W2010849649 type Work @default.
• W2010849649 sameAs 2010849649 @default.
• W2010849649 citedByCount "7" @default.
• W2010849649 countsByYear W20108496492014 @default.
• W2010849649 countsByYear W20108496492016 @default.
• W2010849649 countsByYear W20108496492021 @default.
• W2010849649 crossrefType "journal-article" @default.
• W2010849649 hasAuthorship W2010849649A5012713608 @default.
• W2010849649 hasAuthorship W2010849649A5031680484 @default.
• W2010849649 hasAuthorship W2010849649A5087391729 @default.
• W2010849649 hasConcept C105795698 @default.
• W2010849649 hasConcept C121332964 @default.
• W2010849649 hasConcept C121864883 @default.
• W2010849649 hasConcept C134306372 @default.
• W2010849649 hasConcept C147789679 @default.
• W2010849649 hasConcept C1491633281 @default.
• W2010849649 hasConcept C158622935 @default.
• W2010849649 hasConcept C185592680 @default.
• W2010849649 hasConcept C186060115 @default.
• W2010849649 hasConcept C18762648 @default.
• W2010849649 hasConcept C28826006 @default.
• W2010849649 hasConcept C29537977 @default.
• W2010849649 hasConcept C33923547 @default.
• W2010849649 hasConcept C51544822 @default.
• W2010849649 hasConcept C55493867 @default.
• W2010849649 hasConcept C62520636 @default.
• W2010849649 hasConcept C76969082 @default.
• W2010849649 hasConcept C78045399 @default.
• W2010849649 hasConcept C8171440 @default.
• W2010849649 hasConcept C86803240 @default.
• W2010849649 hasConcept C97355855 @default.
• W2010849649 hasConceptScore W2010849649C105795698 @default.
• W2010849649 hasConceptScore W2010849649C121332964 @default.
• W2010849649 hasConceptScore W2010849649C121864883 @default.
• W2010849649 hasConceptScore W2010849649C134306372 @default.
• W2010849649 hasConceptScore W2010849649C147789679 @default.
• W2010849649 hasConceptScore W2010849649C1491633281 @default.
• W2010849649 hasConceptScore W2010849649C158622935 @default.
• W2010849649 hasConceptScore W2010849649C185592680 @default.
• W2010849649 hasConceptScore W2010849649C186060115 @default.
• W2010849649 hasConceptScore W2010849649C18762648 @default.
• W2010849649 hasConceptScore W2010849649C28826006 @default.
• W2010849649 hasConceptScore W2010849649C29537977 @default.
• W2010849649 hasConceptScore W2010849649C33923547 @default.
• W2010849649 hasConceptScore W2010849649C51544822 @default.
• W2010849649 hasConceptScore W2010849649C55493867 @default.
• W2010849649 hasConceptScore W2010849649C62520636 @default.
• W2010849649 hasConceptScore W2010849649C76969082 @default.
• W2010849649 hasConceptScore W2010849649C78045399 @default.
• W2010849649 hasConceptScore W2010849649C8171440 @default.
• W2010849649 hasConceptScore W2010849649C86803240 @default.
• W2010849649 hasConceptScore W2010849649C97355855 @default.
• W2010849649 hasIssue "2" @default.
• W2010849649 hasLocation W20108496491 @default.
• W2010849649 hasOpenAccess W2010849649 @default.
• W2010849649 hasPrimaryLocation W20108496491 @default.
• W2010849649 hasRelatedWork W1974609323 @default.
• W2010849649 hasRelatedWork W2028055751 @default.
• W2010849649 hasRelatedWork W2032151435 @default.
• W2010849649 hasRelatedWork W2037273340 @default.
• W2010849649 hasRelatedWork W2528911914 @default.
• W2010849649 hasRelatedWork W2909304163 @default.
• W2010849649 hasRelatedWork W3047846152 @default.

• next