FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010850871> ?p ?o ?g. }

• W2010850871 endingPage "113" @default.
• W2010850871 startingPage "104" @default.
• W2010850871 abstract "Developmental toxicity can be caused through a multitude of mechanisms and can therefore not be captured through a single simple mechanistic paradigm. However, it may be possible to define a selected group of overarching mechanisms that might allow detection of the vast majority of developmental toxicants. Against this background, we have explored the usefulness of retinoic acid mediated regulation of neural tube and axial patterning as a general mechanism that, when perturbed, may result in manifestations of developmental toxicity that may cover a large part of malformations known to occur in experimental animals and in man. Through a literature survey, we have identified key genes in the regulation of retinoic acid homeostasis, as well as marker genes of neural tube and axial patterning, that may be used to detect developmental toxicants in in vitro systems. A retinoic acid–neural tube/axial patterning adverse outcome pathway (RA–NTA AOP) framework was designed. The framework was tested against existing data of flusilazole exposure in the rat whole embryo culture, the zebrafish embryotoxicity test, and the embryonic stem cell test. Flusilazole is known to interact with retinoic acid homeostasis, and induced common and unique NTA marker gene changes in the three test systems. Flusilazole-induced changes were similar in directionality to gene expression responses after retinoic acid exposure. It is suggested that the RA–NTA framework may provide a general tool to define mechanistic pathways and biomarkers of developmental toxicity that may be used in alternative in vitro assays for the detection of embryotoxic compounds." @default.
• W2010850871 created "2016-06-24" @default.
• W2010850871 creator A5010620767 @default.
• W2010850871 creator A5060032919 @default.
• W2010850871 creator A5071796957 @default.
• W2010850871 date "2015-08-01" @default.
• W2010850871 modified "2023-09-25" @default.
• W2010850871 title "An adverse outcome pathway framework for neural tube and axial defects mediated by modulation of retinoic acid homeostasis" @default.
• W2010850871 cites W1561979687 @default.
• W2010850871 cites W1872270237 @default.
• W2010850871 cites W1887724877 @default.
• W2010850871 cites W1933423171 @default.
• W2010850871 cites W1964920787 @default.
• W2010850871 cites W1966329590 @default.
• W2010850871 cites W1972879541 @default.
• W2010850871 cites W1976783705 @default.
• W2010850871 cites W1982484840 @default.
• W2010850871 cites W1989519679 @default.
• W2010850871 cites W1990711550 @default.
• W2010850871 cites W1992895406 @default.
• W2010850871 cites W1995137212 @default.
• W2010850871 cites W1998783903 @default.
• W2010850871 cites W2000089305 @default.
• W2010850871 cites W2002923824 @default.
• W2010850871 cites W2003697552 @default.
• W2010850871 cites W2003906235 @default.
• W2010850871 cites W2007123568 @default.
• W2010850871 cites W2007393484 @default.
• W2010850871 cites W2011203208 @default.
• W2010850871 cites W2012345206 @default.
• W2010850871 cites W2014189420 @default.
• W2010850871 cites W2014971526 @default.
• W2010850871 cites W2017661035 @default.
• W2010850871 cites W2019301090 @default.
• W2010850871 cites W2025226012 @default.
• W2010850871 cites W2027601344 @default.
• W2010850871 cites W2033797505 @default.
• W2010850871 cites W2035976525 @default.
• W2010850871 cites W2038304359 @default.
• W2010850871 cites W2038364461 @default.
• W2010850871 cites W2039040529 @default.
• W2010850871 cites W2042406901 @default.
• W2010850871 cites W2049827383 @default.
• W2010850871 cites W2050220315 @default.
• W2010850871 cites W2053345334 @default.
• W2010850871 cites W2056989954 @default.
• W2010850871 cites W2057484444 @default.
• W2010850871 cites W2062369867 @default.
• W2010850871 cites W2067190353 @default.
• W2010850871 cites W2081105512 @default.
• W2010850871 cites W2085842293 @default.
• W2010850871 cites W2087469414 @default.
• W2010850871 cites W2089968837 @default.
• W2010850871 cites W2100306256 @default.
• W2010850871 cites W2102910500 @default.
• W2010850871 cites W2103078752 @default.
• W2010850871 cites W2107429793 @default.
• W2010850871 cites W2110261901 @default.
• W2010850871 cites W2115343453 @default.
• W2010850871 cites W2121308206 @default.
• W2010850871 cites W2122351521 @default.
• W2010850871 cites W2123363472 @default.
• W2010850871 cites W2124676027 @default.
• W2010850871 cites W2128091448 @default.
• W2010850871 cites W2134357235 @default.
• W2010850871 cites W2142635917 @default.
• W2010850871 cites W2147713257 @default.
• W2010850871 cites W2147859366 @default.
• W2010850871 cites W2152867201 @default.
• W2010850871 cites W2153498867 @default.
• W2010850871 cites W2156684099 @default.
• W2010850871 cites W2157106675 @default.
• W2010850871 cites W2159783062 @default.
• W2010850871 cites W2163112976 @default.
• W2010850871 cites W2163918659 @default.
• W2010850871 cites W2166256370 @default.
• W2010850871 cites W2166323465 @default.
• W2010850871 cites W2169032551 @default.
• W2010850871 cites W2171534247 @default.
• W2010850871 cites W2197933972 @default.
• W2010850871 cites W2337949001 @default.
• W2010850871 doi "https://doi.org/10.1016/j.reprotox.2014.10.008" @default.
• W2010850871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25461899" @default.
• W2010850871 hasPublicationYear "2015" @default.
• W2010850871 type Work @default.
• W2010850871 sameAs 2010850871 @default.
• W2010850871 citedByCount "56" @default.
• W2010850871 countsByYear W20108508712014 @default.
• W2010850871 countsByYear W20108508712016 @default.
• W2010850871 countsByYear W20108508712017 @default.
• W2010850871 countsByYear W20108508712018 @default.
• W2010850871 countsByYear W20108508712019 @default.
• W2010850871 countsByYear W20108508712020 @default.
• W2010850871 countsByYear W20108508712021 @default.
• W2010850871 countsByYear W20108508712022 @default.
• W2010850871 countsByYear W20108508712023 @default.
• W2010850871 crossrefType "journal-article" @default.
• W2010850871 hasAuthorship W2010850871A5010620767 @default.

• next