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- W2010871023 abstract "The parasitic microorganism Trypanosoma brucei evades recognition by its host's immune system by repeatedly changing its surface coat. The switch in coat follows a risky route, though: DNA break and repair. Sleeping sickness is caused by the trypanosome parasite. This parasite outwits the human immune system by periodically changing its coat protein in a process known as variant surface glycoprotein (VSG) switching. The favoured model to explain switching invokes a normal host process, called gene conversion, that is used to repair DNA. In this work, Nina Papavasiliou and colleagues establish the first in vitro system that recapitulates VSG switching. The data indicate that a spontaneous double-stranded DNA break upstream of the gene encoding the coat protein initiates the process." @default.
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- W2010871023 date "2009-05-01" @default.
- W2010871023 modified "2023-09-27" @default.
- W2010871023 title "A key event in survival" @default.
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- W2010871023 doi "https://doi.org/10.1038/459172a" @default.
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