FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010872713> ?p ?o ?g. }

• W2010872713 endingPage "711" @default.
• W2010872713 startingPage "704" @default.
• W2010872713 abstract "A 40-yr-old man who had acromegaly and hyperthyroidism due to a GH/TSH-secreting pituitary adenoma is described. Serum free T4 was 2.8 ng/dl, free T3 was 1.1 ng/dl, and TSH was 1.2-1.5 microU/ml; the latter was measured in an immunoradiometric assay with a sensitivity of 0.07 microU/ml. Serum TSH was immunologically identical to standard TSH and did not decrease during a T3 suppression test. Serum free alpha-subunit and the molar alpha-subunit to TSH ratio were high (6.1 ng/ml and 31.2, respectively). TRH administration induced significant increases in both GH (+129%) and alpha-subunit (+156%) levels. Conversely, dopamine infusion resulted in a decrease in serum GH (-66%) and alpha-subunit (-43%) levels, and subsequent administration of the dopamine antagonist sulpiride induced significant increases in both GH and alpha-subunit (+393% and +106%, respectively). Similarly, somatostatin infusion inhibited GH (-43%) and alpha-subunit (-61%) secretion. Serum TSH levels were not affected by TRH, dopamine, or somatostatin. The biological to immunological activity ratio of serum TSH purified by immunoaffinity chromatography and measured in an adenylate cyclase assay was significantly increased compared to that in serum from hypothyroid or euthyroid subjects [biological to immunological activity ratio, 6.9 +/- 0.2 (+/- SD) vs. 4.4 +/- 1.1; P less than 0.001]. In gel chromatography, the apparent mol wt of the patient's TSH was smaller than that of the controls. After adenomectomy, all of the altered parameters of pituitary function became normal. Double gold particle immunostaining of the adenomatous tissue showed that all of the cells contained secretory granules positive for GH and alpha-subunit, while very few cells were positive for TSH beta as well as GH and alpha-subunit. These data indicate that in this patient serum TSH had an apparent mol wt smaller than that of normal TSH and an increased biological activity which, along with the autonomous TSH secretion, account for hyperthyroidism in the presence of low normal TSH levels; alpha-subunit originated from the same adenomatous cells that secreted GH but not TSH, thus explaining the in vivo observation that alpha-subunit responses to several agents were dissociated from TSH responses and parallel to GH responses; and TSH and GH were colocalized in a minority of the neoplastic cells." @default.
• W2010872713 created "2016-06-24" @default.
• W2010872713 creator A5000939289 @default.
• W2010872713 creator A5010730292 @default.
• W2010872713 creator A5023054623 @default.
• W2010872713 creator A5037404198 @default.
• W2010872713 creator A5041064460 @default.
• W2010872713 creator A5052589187 @default.
• W2010872713 creator A5054471634 @default.
• W2010872713 creator A5062388816 @default.
• W2010872713 creator A5072467692 @default.
• W2010872713 creator A5074866428 @default.
• W2010872713 date "1986-04-01" @default.
• W2010872713 modified "2023-09-27" @default.
• W2010872713 title "Endocrine, Biochemical, and Morphlogical Studies of a Pituitary Adenoma Secreting Growth Hormone, Thyrotropin (TSH), and α-Subunit: Evidence for Secretion of TSH with Increased Bioactivity*" @default.
• W2010872713 cites W117103671 @default.
• W2010872713 cites W1984041946 @default.
• W2010872713 cites W1984963251 @default.
• W2010872713 cites W1990112088 @default.
• W2010872713 cites W2002402719 @default.
• W2010872713 cites W2004859554 @default.
• W2010872713 cites W2005431199 @default.
• W2010872713 cites W2006359830 @default.
• W2010872713 cites W2013135257 @default.
• W2010872713 cites W2015625085 @default.
• W2010872713 cites W2016664345 @default.
• W2010872713 cites W2017083989 @default.
• W2010872713 cites W2019386082 @default.
• W2010872713 cites W2022800353 @default.
• W2010872713 cites W2025227879 @default.
• W2010872713 cites W2025708134 @default.
• W2010872713 cites W2026528731 @default.
• W2010872713 cites W2031192188 @default.
• W2010872713 cites W2031697036 @default.
• W2010872713 cites W2033122298 @default.
• W2010872713 cites W2051033476 @default.
• W2010872713 cites W2054089903 @default.
• W2010872713 cites W2063975000 @default.
• W2010872713 cites W2064963775 @default.
• W2010872713 cites W2074188044 @default.
• W2010872713 cites W2074485908 @default.
• W2010872713 cites W2164616699 @default.
• W2010872713 cites W2166624362 @default.
• W2010872713 cites W2415488776 @default.
• W2010872713 cites W2017922334 @default.
• W2010872713 doi "https://doi.org/10.1210/jcem-62-4-704" @default.
• W2010872713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2419356" @default.
• W2010872713 hasPublicationYear "1986" @default.
• W2010872713 type Work @default.
• W2010872713 sameAs 2010872713 @default.
• W2010872713 citedByCount "93" @default.
• W2010872713 countsByYear W20108727132013 @default.
• W2010872713 countsByYear W20108727132014 @default.
• W2010872713 countsByYear W20108727132016 @default.
• W2010872713 countsByYear W20108727132017 @default.
• W2010872713 countsByYear W20108727132018 @default.
• W2010872713 countsByYear W20108727132019 @default.
• W2010872713 countsByYear W20108727132020 @default.
• W2010872713 countsByYear W20108727132021 @default.
• W2010872713 countsByYear W20108727132022 @default.
• W2010872713 crossrefType "journal-article" @default.
• W2010872713 hasAuthorship W2010872713A5000939289 @default.
• W2010872713 hasAuthorship W2010872713A5010730292 @default.
• W2010872713 hasAuthorship W2010872713A5023054623 @default.
• W2010872713 hasAuthorship W2010872713A5037404198 @default.
• W2010872713 hasAuthorship W2010872713A5041064460 @default.
• W2010872713 hasAuthorship W2010872713A5052589187 @default.
• W2010872713 hasAuthorship W2010872713A5054471634 @default.
• W2010872713 hasAuthorship W2010872713A5062388816 @default.
• W2010872713 hasAuthorship W2010872713A5072467692 @default.
• W2010872713 hasAuthorship W2010872713A5074866428 @default.
• W2010872713 hasBestOaLocation W20108727131 @default.
• W2010872713 hasConcept C104292427 @default.
• W2010872713 hasConcept C104317684 @default.
• W2010872713 hasConcept C126322002 @default.
• W2010872713 hasConcept C134018914 @default.
• W2010872713 hasConcept C176685330 @default.
• W2010872713 hasConcept C185592680 @default.
• W2010872713 hasConcept C2776216936 @default.
• W2010872713 hasConcept C2776297358 @default.
• W2010872713 hasConcept C2777195454 @default.
• W2010872713 hasConcept C2777428134 @default.
• W2010872713 hasConcept C2777433750 @default.
• W2010872713 hasConcept C2777658017 @default.
• W2010872713 hasConcept C2778758028 @default.
• W2010872713 hasConcept C2779064019 @default.
• W2010872713 hasConcept C2779318953 @default.
• W2010872713 hasConcept C2984496839 @default.
• W2010872713 hasConcept C4134927 @default.
• W2010872713 hasConcept C55493867 @default.
• W2010872713 hasConcept C71315377 @default.
• W2010872713 hasConcept C71924100 @default.
• W2010872713 hasConcept C83730767 @default.
• W2010872713 hasConceptScore W2010872713C104292427 @default.
• W2010872713 hasConceptScore W2010872713C104317684 @default.
• W2010872713 hasConceptScore W2010872713C126322002 @default.
• W2010872713 hasConceptScore W2010872713C134018914 @default.
• W2010872713 hasConceptScore W2010872713C176685330 @default.

• next