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- W2010877040 abstract "Abstract The effects of antidepressive drugs were studied on estrus behaviour activated in ovariectomised rats by progesterone, tetrabenazine or reserpine in combination with estrogen. On tetrabenazine‐ activated estrus behaviour an inhibitory effect was obtained by imipramine, desmethylimipramine, amitriptyline and nortriptyline, but not by trimeprimine. All the mentioned antidepressive compounds reduced the progesterone activated heat response; however, trimeprimine and nortriptyline were effective only when comparatively high doses were used and furthermore the effect was short‐lasting. Reserpine‐activated estrus behaviour was inhibited by imipramine; other drugs were not tested. Imipramine and the monoamine oxidase inhibitors pargyline and nialamide acted synergistically in inhibiting progesterone‐activated estrus behaviour. There was no relation between the inhibitory effect on tetrabenazine activated estrus behaviour and the ability of the different antidepressant drugs to prevent tetrabenazine induced sedation or to induce hyperactivity (compulsive exploring behaviour). The present data further support the earlier suggestion that there exist serotoninergic pathways mediating inhibition of estrus behaviour. It seems that the antidepressive compounds studied potentiate central serotoninergic mechanisms." @default.
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- W2010877040 title "The Effect of Imipramine and Related Antidepressive Drugs on Estrus Behaviour in Ovariectomised Rats Activated by Progesterone, Reserpine or Tetrabenazine in Combination with Estrogen" @default.
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- W2010877040 doi "https://doi.org/10.1111/j.1748-1716.1966.tb03328.x" @default.
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