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- W2010881689 abstract "<b>Objective</b> The aim of this study is to determine the use of an early clinical signs and symptoms warning tool in early identification of intestinal dysfunction as a clinical strategy to decrease necrotizing enterocolitis (NEC) severity. <b>Design</b> Using signs and symptoms of 297 infants, of which 33 infants were diagnosed with stage II and III EC intestinal dysfunction, a five clinical category scoring tool (<u>Neo</u>natal <u>N</u>ecrotizing <u>E</u>nterocolitis <u>E</u>arly <u>D</u>etection <u>S</u>core [NeoNEEDS]) and strategy with abdominal X-ray alert was developed. The categories included behavior, cardiac, respiratory, gastrointestinal, and feeding tolerance. The strategy was tested in a prospective cohort of 72 infants < 1,500 g, utilizing 532 observations between 10/2012 and 9/1/2013. The statistical analysis utilized the Statistical Analysis Software (SAS). <b>Results</b> The earliest signs and symptoms of intestinal dysfunction (Stage I NEC) were cardiorespiratory baseline changes, <i>p</i> < 0.001. Abdominal distension and/or feeding intolerance were late findings associated with stage II or III NEC. Tool scores ≥ 5 predicted intestinal dysfunction (<i>p</i> < 0.00). Sensitivity was high (95%) with specificity of 82% and positive and negative predictive values of 76% and 95%, respectively. Use of the tool during the study period was associated with decreased NEC severity rates (Bell NEC stage II and III). <b>Conclusion</b> Cardiorespiratory symptoms precede gastrointestinal symptoms of intestinal dysfunction. Targeting signs and symptoms in an early warning tool to identify intestinal dysfunction can impact NEC severity progression." @default.
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- W2010881689 date "2015-03-23" @default.
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- W2010881689 title "Early Detection Tool of Intestinal Dysfunction: Impact on Necrotizing Enterocolitis Severity" @default.
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- W2010881689 doi "https://doi.org/10.1055/s-0034-1543984" @default.
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