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- W2010898269 abstract "In the presence of 0.5 mm EGT A (a calcium chelator), the muscarinic agonist carbachol at 0.1 mm inhibited octopamine-stimulated cyclic AMP (cAMP) production in intact ventral nerve cords of Periplaneta americana. This effect was reduced by the addition of 0.1 mm atropine (a muscarinic antagonist), suggesting that the effect is mediated via muscarinic acetylcholine receptors (mAChR). This inhibitory effect of carbachol was not observed in the synaptosomes of nerve cords, suggesting that the inhibitory effect was not due to direct coupling of the mAChR to adenylate cyclase but mediated by other second messengers. The inhibitory effect seems to be due to an increase in the intracellular calcium level. In the presence of exogeneous extracellular 0.25 mm Ca2 + the octopamine-stimulated cAMP production was lower than that in the absence of extracellular Ca2 +, and the cAMP levels were not further reduced by adding carbachol to the octopamine-stimulated cAMP production system. Washing did not remove all of the ..." @default.
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- W2010898269 date "1991-01-01" @default.
- W2010898269 modified "2023-10-14" @default.
- W2010898269 title "Effects of a Muscarinic Agonist on Octopamine-stimulated Cyclic AMP Production in American Cockroach(Periplaneta americana)Nerve Cords." @default.
- W2010898269 doi "https://doi.org/10.1271/bbb1961.55.2547" @default.
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