Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010899240> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2010899240 endingPage "34S" @default.
- W2010899240 startingPage "28S" @default.
- W2010899240 abstract "Dipeptidyl peptidases (DPP) are ubiquitous enzymes. Several DPPs have been described and the most known among them is dipeptidyl peptidase IV, a type II multifunctional cell surface protein that belong to the prolyl oligopeptidase family of serine proteases. DPP IV specifically cleaves dipeptides from the N-terminus of peptides with a Pro, Hyp or Ala in the penultimate position. DPP IV substrates include certain chemokines, growth factors (e.g. growth hormone, growth hormone-releasing factor, glucagon-like peptides 1 and 2) and neuro- and vasoactive peptides including neuropeptide Y, peptide YY and substance P. In this work, we present the identification of a dipeptidyl peptidase from Trypanosoma brucei (DPPTb). Its gene was isolated by PCR using primers designed from T. brucei ESTs sequences that matched with human DPP IV. However, the cloned and sequenced insert obtained displays similarity mainly with human DPP8 and DPP9. Active recombinant DPP Tb was expressed in insect cells using the baculovirus system. We observed by immunofluorescence, using anti-DPPTb antibodies, that native DPPTb is localized in vesicles in the cytoplasm from procyclic forms of T. brucei." @default.
- W2010899240 created "2016-06-24" @default.
- W2010899240 creator A5009280552 @default.
- W2010899240 creator A5037905322 @default.
- W2010899240 creator A5083256606 @default.
- W2010899240 date "2005-03-01" @default.
- W2010899240 modified "2023-10-17" @default.
- W2010899240 title "Identification of a dipeptidyl peptidase from Trypanosoma brucei" @default.
- W2010899240 doi "https://doi.org/10.1111/j.1550-7408.2005.05202003_3_18.x" @default.
- W2010899240 hasPublicationYear "2005" @default.
- W2010899240 type Work @default.
- W2010899240 sameAs 2010899240 @default.
- W2010899240 citedByCount "0" @default.
- W2010899240 crossrefType "journal-article" @default.
- W2010899240 hasAuthorship W2010899240A5009280552 @default.
- W2010899240 hasAuthorship W2010899240A5037905322 @default.
- W2010899240 hasAuthorship W2010899240A5083256606 @default.
- W2010899240 hasConcept C104317684 @default.
- W2010899240 hasConcept C134018914 @default.
- W2010899240 hasConcept C153911025 @default.
- W2010899240 hasConcept C156490143 @default.
- W2010899240 hasConcept C181199279 @default.
- W2010899240 hasConcept C2776714187 @default.
- W2010899240 hasConcept C2777180221 @default.
- W2010899240 hasConcept C2777807008 @default.
- W2010899240 hasConcept C2779502636 @default.
- W2010899240 hasConcept C2780043585 @default.
- W2010899240 hasConcept C2781469919 @default.
- W2010899240 hasConcept C55493867 @default.
- W2010899240 hasConcept C555293320 @default.
- W2010899240 hasConcept C86803240 @default.
- W2010899240 hasConceptScore W2010899240C104317684 @default.
- W2010899240 hasConceptScore W2010899240C134018914 @default.
- W2010899240 hasConceptScore W2010899240C153911025 @default.
- W2010899240 hasConceptScore W2010899240C156490143 @default.
- W2010899240 hasConceptScore W2010899240C181199279 @default.
- W2010899240 hasConceptScore W2010899240C2776714187 @default.
- W2010899240 hasConceptScore W2010899240C2777180221 @default.
- W2010899240 hasConceptScore W2010899240C2777807008 @default.
- W2010899240 hasConceptScore W2010899240C2779502636 @default.
- W2010899240 hasConceptScore W2010899240C2780043585 @default.
- W2010899240 hasConceptScore W2010899240C2781469919 @default.
- W2010899240 hasConceptScore W2010899240C55493867 @default.
- W2010899240 hasConceptScore W2010899240C555293320 @default.
- W2010899240 hasConceptScore W2010899240C86803240 @default.
- W2010899240 hasIssue "2" @default.
- W2010899240 hasLocation W20108992401 @default.
- W2010899240 hasOpenAccess W2010899240 @default.
- W2010899240 hasPrimaryLocation W20108992401 @default.
- W2010899240 hasRelatedWork W1980724829 @default.
- W2010899240 hasRelatedWork W1995339003 @default.
- W2010899240 hasRelatedWork W2006728920 @default.
- W2010899240 hasRelatedWork W2010899240 @default.
- W2010899240 hasRelatedWork W2011021892 @default.
- W2010899240 hasRelatedWork W2035316083 @default.
- W2010899240 hasRelatedWork W2048332139 @default.
- W2010899240 hasRelatedWork W2081319101 @default.
- W2010899240 hasRelatedWork W2100819581 @default.
- W2010899240 hasRelatedWork W2324208869 @default.
- W2010899240 hasVolume "52" @default.
- W2010899240 isParatext "false" @default.
- W2010899240 isRetracted "false" @default.
- W2010899240 magId "2010899240" @default.
- W2010899240 workType "article" @default.