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- W2010901326 endingPage "568" @default.
- W2010901326 startingPage "561" @default.
- W2010901326 abstract "Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Despite progress in identifying hallmark genetic alterations associated with the main subtypes of epithelial ovarian cancer, the survival rate of women with EOC changed little since platinum-based treatment was introduced more than 30years ago. The successful identification of new, effective anticancer drugs largely depends on appropriate preclinical experimental models that should ideally mimic the complexity of different cancer forms. This review examines the preclinical ovarian cancer models available for a better understanding of the biological mechanisms of the development, progression, invasion and metastasis of EOC. We provide evidence that the preclinical models have been instrumental for a better understanding of the pathological events at the basis of ovarian carcinoma. The genetically engineered mouse (GEM) models of ovarian cancer have overcome some of the weaknesses of the xenograft models, such as the fact that these tumors arise orthotopically in immunologically intact mice and more closely resemble the behavior of human cancers. We envisage that in the near future these GEM models will play a key role in pre-selecting drug regimens with the greatest promise of efficacy in human clinical trials, making it easier and certainly less expensive to test new, different drug combinations." @default.
- W2010901326 created "2016-06-24" @default.
- W2010901326 creator A5023757905 @default.
- W2010901326 creator A5038885031 @default.
- W2010901326 creator A5091714925 @default.
- W2010901326 date "2013-10-01" @default.
- W2010901326 modified "2023-09-27" @default.
- W2010901326 title "Revisiting ovarian cancer preclinical models: Implications for a better management of the disease" @default.
- W2010901326 cites W101497454 @default.
- W2010901326 cites W112569523 @default.
- W2010901326 cites W1504437329 @default.
- W2010901326 cites W1523531555 @default.
- W2010901326 cites W1547447592 @default.
- W2010901326 cites W1564192982 @default.
- W2010901326 cites W1589370930 @default.
- W2010901326 cites W159782486 @default.
- W2010901326 cites W1724512254 @default.
- W2010901326 cites W1853532732 @default.
- W2010901326 cites W1961928411 @default.
- W2010901326 cites W1965813208 @default.
- W2010901326 cites W1967187359 @default.
- W2010901326 cites W1967900925 @default.
- W2010901326 cites W1973268287 @default.
- W2010901326 cites W1974756790 @default.
- W2010901326 cites W1981004976 @default.
- W2010901326 cites W1982867676 @default.
- W2010901326 cites W1983248140 @default.
- W2010901326 cites W1983359126 @default.
- W2010901326 cites W1984250533 @default.
- W2010901326 cites W1992252639 @default.
- W2010901326 cites W1994772304 @default.
- W2010901326 cites W1996066317 @default.
- W2010901326 cites W1997203401 @default.
- W2010901326 cites W1997793743 @default.
- W2010901326 cites W1998291423 @default.
- W2010901326 cites W1998534698 @default.
- W2010901326 cites W2001962377 @default.
- W2010901326 cites W2006691850 @default.
- W2010901326 cites W2012084975 @default.
- W2010901326 cites W2012370112 @default.
- W2010901326 cites W2014021169 @default.
- W2010901326 cites W2016968637 @default.
- W2010901326 cites W2018360235 @default.
- W2010901326 cites W2024551953 @default.
- W2010901326 cites W2026320096 @default.
- W2010901326 cites W2026674119 @default.
- W2010901326 cites W2028353265 @default.
- W2010901326 cites W2029189318 @default.
- W2010901326 cites W2031979674 @default.
- W2010901326 cites W2034680056 @default.
- W2010901326 cites W2035971989 @default.
- W2010901326 cites W2036242349 @default.
- W2010901326 cites W2037325146 @default.
- W2010901326 cites W2037959202 @default.
- W2010901326 cites W2038472905 @default.
- W2010901326 cites W2041195664 @default.
- W2010901326 cites W2041766813 @default.
- W2010901326 cites W2044464259 @default.
- W2010901326 cites W2051239163 @default.
- W2010901326 cites W2053952403 @default.
- W2010901326 cites W2054690981 @default.
- W2010901326 cites W2056739417 @default.
- W2010901326 cites W2056785598 @default.
- W2010901326 cites W2059143304 @default.
- W2010901326 cites W2059643491 @default.
- W2010901326 cites W2060524209 @default.
- W2010901326 cites W2062495971 @default.
- W2010901326 cites W2065036320 @default.
- W2010901326 cites W2068085420 @default.
- W2010901326 cites W2069662317 @default.
- W2010901326 cites W2071014344 @default.
- W2010901326 cites W2071755701 @default.
- W2010901326 cites W2074982201 @default.
- W2010901326 cites W2075092306 @default.
- W2010901326 cites W2075711878 @default.
- W2010901326 cites W2077037952 @default.
- W2010901326 cites W2077484102 @default.
- W2010901326 cites W2079707111 @default.
- W2010901326 cites W2079822637 @default.
- W2010901326 cites W2088380527 @default.
- W2010901326 cites W2088601895 @default.
- W2010901326 cites W2092440654 @default.
- W2010901326 cites W2093634476 @default.
- W2010901326 cites W2094829108 @default.
- W2010901326 cites W2095981921 @default.
- W2010901326 cites W2096065464 @default.
- W2010901326 cites W2097308038 @default.
- W2010901326 cites W2097525296 @default.
- W2010901326 cites W2106439593 @default.
- W2010901326 cites W2109067479 @default.
- W2010901326 cites W2110017381 @default.
- W2010901326 cites W2112499249 @default.
- W2010901326 cites W2113122060 @default.
- W2010901326 cites W2113632677 @default.
- W2010901326 cites W2114852376 @default.
- W2010901326 cites W2116010079 @default.
- W2010901326 cites W2118667301 @default.
- W2010901326 cites W2119651686 @default.