FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010912190> ?p ?o ?g. }

• W2010912190 abstract "Bacterial persistence describes a phenomenon wherein a small subpopulation of cells is able to survive a challenge with high doses of an antibiotic (or other stressor) better than the majority of the population. Previous work has shown that cells that are in a dormant or slow-growing state are persistent to antibiotic treatment and that populations with higher fractions of dormant cells exhibit higher levels of persistence. These data suggest that a major determinant of the fraction of persisters within a population is the rate at which cells enter and exit from dormancy. However, it is not known whether there are physiological changes in addition to dormancy that influence persistence. Here, we use quantitative measurements of persister fractions in a set of environmental isolates of E. coli together with a mathematical model of persister formation to test whether a single general physiological change, such as cell dormancy, can explain the differences in persister phenotypes observed in different strains.If a single physiological change (e.g. cell dormancy) underlies most persister phenotypes, then strains should exhibit characteristic fractions of persister cells: some strains will consistently have high fractions of persisters (dormant cells), whereas others will have low fractions. Although we found substantial variation in the fraction of persisters between different environmental isolates of E. coli, these fractions were not correlated across antibiotics. Some strains exhibited high persister fractions in one antibiotic, but low persister fractions in a second antibiotic. Surprisingly, no correlation in persister fractions was observed between any two drugs, even for antibiotics with nearly identical modes of action (ciprofloxacin and nalidixic acid).These data support the hypothesis that there is no single physiological change that determines the persistence level in a population of cells. Instead, the fraction of cells that survive antibiotic treatment (persist) depends critically on the specific antibiotic that is used, suggesting that physiological changes in addition to dormancy can underlie persister phenotypes." @default.
• W2010912190 created "2016-06-24" @default.
• W2010912190 creator A5017960972 @default.
• W2010912190 creator A5035184564 @default.
• W2010912190 creator A5052508586 @default.
• W2010912190 date "2013-02-04" @default.
• W2010912190 modified "2023-10-12" @default.
• W2010912190 title "Quantitative analysis of persister fractions suggests different mechanisms of formation among environmental isolates of E. coli" @default.
• W2010912190 cites W1666867306 @default.
• W2010912190 cites W1979530643 @default.
• W2010912190 cites W1992572387 @default.
• W2010912190 cites W1997520863 @default.
• W2010912190 cites W2009677733 @default.
• W2010912190 cites W2017165733 @default.
• W2010912190 cites W2028748512 @default.
• W2010912190 cites W2045825103 @default.
• W2010912190 cites W2052125364 @default.
• W2010912190 cites W2054114849 @default.
• W2010912190 cites W2059410416 @default.
• W2010912190 cites W2075329036 @default.
• W2010912190 cites W2076073652 @default.
• W2010912190 cites W2083581925 @default.
• W2010912190 cites W2091301347 @default.
• W2010912190 cites W2095833414 @default.
• W2010912190 cites W2101366952 @default.
• W2010912190 cites W2102114757 @default.
• W2010912190 cites W2107517822 @default.
• W2010912190 cites W2107600014 @default.
• W2010912190 cites W2109710880 @default.
• W2010912190 cites W2110926912 @default.
• W2010912190 cites W2115519453 @default.
• W2010912190 cites W2117834417 @default.
• W2010912190 cites W2124562476 @default.
• W2010912190 cites W2130825211 @default.
• W2010912190 cites W2142417013 @default.
• W2010912190 cites W2143261292 @default.
• W2010912190 cites W2145676608 @default.
• W2010912190 cites W2146562282 @default.
• W2010912190 cites W2148323109 @default.
• W2010912190 cites W2153148799 @default.
• W2010912190 cites W2161755384 @default.
• W2010912190 cites W2168606178 @default.
• W2010912190 cites W4213353716 @default.
• W2010912190 doi "https://doi.org/10.1186/1471-2180-13-25" @default.
• W2010912190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3682893" @default.
• W2010912190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23379956" @default.
• W2010912190 hasPublicationYear "2013" @default.
• W2010912190 type Work @default.
• W2010912190 sameAs 2010912190 @default.
• W2010912190 citedByCount "65" @default.
• W2010912190 countsByYear W20109121902013 @default.
• W2010912190 countsByYear W20109121902014 @default.
• W2010912190 countsByYear W20109121902015 @default.
• W2010912190 countsByYear W20109121902016 @default.
• W2010912190 countsByYear W20109121902017 @default.
• W2010912190 countsByYear W20109121902018 @default.
• W2010912190 countsByYear W20109121902019 @default.
• W2010912190 countsByYear W20109121902020 @default.
• W2010912190 countsByYear W20109121902021 @default.
• W2010912190 countsByYear W20109121902022 @default.
• W2010912190 countsByYear W20109121902023 @default.
• W2010912190 crossrefType "journal-article" @default.
• W2010912190 hasAuthorship W2010912190A5017960972 @default.
• W2010912190 hasAuthorship W2010912190A5035184564 @default.
• W2010912190 hasAuthorship W2010912190A5052508586 @default.
• W2010912190 hasBestOaLocation W20109121901 @default.
• W2010912190 hasConcept C100701293 @default.
• W2010912190 hasConcept C127413603 @default.
• W2010912190 hasConcept C136622501 @default.
• W2010912190 hasConcept C144024400 @default.
• W2010912190 hasConcept C149923435 @default.
• W2010912190 hasConcept C187320778 @default.
• W2010912190 hasConcept C2781009140 @default.
• W2010912190 hasConcept C2908647359 @default.
• W2010912190 hasConcept C3527866 @default.
• W2010912190 hasConcept C501593827 @default.
• W2010912190 hasConcept C523546767 @default.
• W2010912190 hasConcept C54355233 @default.
• W2010912190 hasConcept C58123911 @default.
• W2010912190 hasConcept C59822182 @default.
• W2010912190 hasConcept C86803240 @default.
• W2010912190 hasConcept C89423630 @default.
• W2010912190 hasConceptScore W2010912190C100701293 @default.
• W2010912190 hasConceptScore W2010912190C127413603 @default.
• W2010912190 hasConceptScore W2010912190C136622501 @default.
• W2010912190 hasConceptScore W2010912190C144024400 @default.
• W2010912190 hasConceptScore W2010912190C149923435 @default.
• W2010912190 hasConceptScore W2010912190C187320778 @default.
• W2010912190 hasConceptScore W2010912190C2781009140 @default.
• W2010912190 hasConceptScore W2010912190C2908647359 @default.
• W2010912190 hasConceptScore W2010912190C3527866 @default.
• W2010912190 hasConceptScore W2010912190C501593827 @default.
• W2010912190 hasConceptScore W2010912190C523546767 @default.
• W2010912190 hasConceptScore W2010912190C54355233 @default.
• W2010912190 hasConceptScore W2010912190C58123911 @default.
• W2010912190 hasConceptScore W2010912190C59822182 @default.
• W2010912190 hasConceptScore W2010912190C86803240 @default.
• W2010912190 hasConceptScore W2010912190C89423630 @default.
• W2010912190 hasIssue "1" @default.
• W2010912190 hasLocation W20109121901 @default.

• next