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- W2010913288 abstract "Abstract Background Perinatal asphyxia is associated with cardiac dysfunction, and it is important to prevent further tissue injury during resuscitation. There is increasing evidence that myocardial matrix metalloproteinases (MMPs) are involved in myocardial hypoxaemia–reoxygenation injury. Objective To assess MMPs and antioxidant capacity in newborn pigs after global ischaemia and subsequent resuscitation with ambient air or 100% O 2 at different PaCO 2 ‐levels. Methods Newborn pigs (12–36 h of age) were resuscitated for 30 min by ventilation with 21% or 100% O 2 at different PaCO 2 levels after a hypoxic insult, and thereafter observed for 150 min. In myocardial tissue extracts, MMPs were analyzed by gelatin zymography and broad matrix‐degrading capacity (total MMP). Total endogenous antioxidant capacity in myocardial tissue extracts was measured by the oxygen radical absorbance capacity (ORAC) assay. Results Matrix metalloproteinase‐2 more than doubled from baseline values ( P < 0·001), and was higher in piglets resuscitated with 100% O 2 than with ambient air ( P = 0·012). The ORAC value was considerably decreased ( P < 0·001). In piglets with elevated PaCO 2 , total MMP‐activity in the right ventricle was more increased than in the left ventricle ( P = 0·008). In the left ventricle, total MMPactivity was higher in the piglets with low PaCO 2 than in the piglets with elevated PaCO 2 ( P = 0·013). Conclusion In hypoxaemia‐reoxygenation injury the MMP‐2 level was highly increased and was most elevated in the piglets resuscitated with 100% O 2 . Antioxidant capacity was considerably decreased. Assessed by total MMP‐activity, elevated PaCO 2 during resuscitation might protect the left ventricle, and probably increase right ventricle injury of the myocardium." @default.
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- W2010913288 date "2004-07-01" @default.
- W2010913288 modified "2023-10-15" @default.
- W2010913288 title "Increased myocardial matrix metalloproteinases in hypoxic newborn pigs during resuscitation: effects of oxygen and carbon dioxide" @default.
- W2010913288 cites W1518189745 @default.
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- W2010913288 cites W1894541755 @default.
- W2010913288 cites W1971653265 @default.
- W2010913288 cites W1982630397 @default.
- W2010913288 cites W1995457093 @default.
- W2010913288 cites W1998305917 @default.
- W2010913288 cites W2005707246 @default.
- W2010913288 cites W201062702 @default.
- W2010913288 cites W2013501481 @default.
- W2010913288 cites W2031203524 @default.
- W2010913288 cites W2037421213 @default.
- W2010913288 cites W2038633055 @default.
- W2010913288 cites W2043008718 @default.
- W2010913288 cites W2051000112 @default.
- W2010913288 cites W2051245896 @default.
- W2010913288 cites W2054003361 @default.
- W2010913288 cites W2057713220 @default.
- W2010913288 cites W2058523630 @default.
- W2010913288 cites W2059215187 @default.
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- W2010913288 cites W2164160223 @default.
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- W2010913288 cites W2176503073 @default.
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- W2010913288 cites W2274392996 @default.
- W2010913288 cites W2279828564 @default.
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- W2010913288 cites W4250908540 @default.
- W2010913288 cites W95052302 @default.
- W2010913288 doi "https://doi.org/10.1111/j.1365-2362.2004.01378.x" @default.
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