Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010919563> ?p ?o ?g. }
- W2010919563 endingPage "41" @default.
- W2010919563 startingPage "34" @default.
- W2010919563 abstract "Epithelial-mesenchymal transition (EMT) plays an important role in progress of renal allograft fibrosis. The adenovirus-mediated anti-sense extracellular signal-regulated kinase 2 (Adanti-ERK2) gene therapy was used to block ERK signaling pathway, and its effect on EMT and renal allograft fibrosis both in vivo and in vitro was explored.We first generated an in vitro EMT model by connective tissue growth factor (CTGF) stimulation in a HK-2 cell culture system, and then applied Adanti-ERK2 gene therapy on it. The transition of epithelial marker (E-cadherin) to mesenchymal markers (α-SMA, Vimentin) and the cell mobility function alteration were monitored for the observation of EMT progress. In vivo, a rat renal transplant model with Fisher-Lewis combination was employed and the Adanti-ERK2 gene therapy was given. The tubular EMT changes and pathology of allograft fibrosis were examined.In vitro, Adanti-ERK2 gene therapy inhibited CTGF-induced tubular EMT and attenuated the cell motility function induced by CTGF. In vivo, Adanti-ERK2 gene therapy attenuated tubular EMT, modulated the infiltration of macrophages and CD8(+), CD4(+)T lymphocytes, and ameliorated fibrosis effectively in the renal allografts 24weeks after transplantation.Adanti-ERK2 gene therapy inhibits tubular EMT and attenuates renal allograft fibrosis. It is possible to develop promising molecular drug(s) in the future based on ERK signaling pathway." @default.
- W2010919563 created "2016-06-24" @default.
- W2010919563 creator A5012271537 @default.
- W2010919563 creator A5017087775 @default.
- W2010919563 creator A5040452414 @default.
- W2010919563 creator A5041462354 @default.
- W2010919563 creator A5045365947 @default.
- W2010919563 creator A5083420537 @default.
- W2010919563 creator A5091070290 @default.
- W2010919563 date "2011-07-01" @default.
- W2010919563 modified "2023-09-23" @default.
- W2010919563 title "Adenovirus-mediated anti-sense ERK2 gene therapy inhibits tubular epithelial–mesenchymal transition and ameliorates renal allograft fibrosis" @default.
- W2010919563 cites W189956990 @default.
- W2010919563 cites W1964177773 @default.
- W2010919563 cites W1969743955 @default.
- W2010919563 cites W1979757651 @default.
- W2010919563 cites W1982010552 @default.
- W2010919563 cites W1984016029 @default.
- W2010919563 cites W1995791071 @default.
- W2010919563 cites W2001235080 @default.
- W2010919563 cites W2002664770 @default.
- W2010919563 cites W2020941127 @default.
- W2010919563 cites W2026707459 @default.
- W2010919563 cites W2027612386 @default.
- W2010919563 cites W2028073939 @default.
- W2010919563 cites W2031547967 @default.
- W2010919563 cites W2035921789 @default.
- W2010919563 cites W2038732581 @default.
- W2010919563 cites W2053428121 @default.
- W2010919563 cites W2057463986 @default.
- W2010919563 cites W2068220646 @default.
- W2010919563 cites W2070989417 @default.
- W2010919563 cites W2076540081 @default.
- W2010919563 cites W2092240515 @default.
- W2010919563 cites W2092512001 @default.
- W2010919563 cites W2092634429 @default.
- W2010919563 cites W2096314064 @default.
- W2010919563 cites W2098974363 @default.
- W2010919563 cites W2108499860 @default.
- W2010919563 cites W2112666597 @default.
- W2010919563 cites W2116762319 @default.
- W2010919563 cites W2122057254 @default.
- W2010919563 cites W2123233663 @default.
- W2010919563 cites W2137759284 @default.
- W2010919563 cites W2138620116 @default.
- W2010919563 cites W2148184356 @default.
- W2010919563 cites W2150621637 @default.
- W2010919563 cites W2153561801 @default.
- W2010919563 cites W2162013743 @default.
- W2010919563 cites W2166460301 @default.
- W2010919563 cites W4244774747 @default.
- W2010919563 cites W4250731522 @default.
- W2010919563 doi "https://doi.org/10.1016/j.trim.2011.04.001" @default.
- W2010919563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21530658" @default.
- W2010919563 hasPublicationYear "2011" @default.
- W2010919563 type Work @default.
- W2010919563 sameAs 2010919563 @default.
- W2010919563 citedByCount "11" @default.
- W2010919563 countsByYear W20109195632012 @default.
- W2010919563 countsByYear W20109195632013 @default.
- W2010919563 countsByYear W20109195632014 @default.
- W2010919563 countsByYear W20109195632015 @default.
- W2010919563 countsByYear W20109195632016 @default.
- W2010919563 countsByYear W20109195632017 @default.
- W2010919563 countsByYear W20109195632018 @default.
- W2010919563 countsByYear W20109195632019 @default.
- W2010919563 crossrefType "journal-article" @default.
- W2010919563 hasAuthorship W2010919563A5012271537 @default.
- W2010919563 hasAuthorship W2010919563A5017087775 @default.
- W2010919563 hasAuthorship W2010919563A5040452414 @default.
- W2010919563 hasAuthorship W2010919563A5041462354 @default.
- W2010919563 hasAuthorship W2010919563A5045365947 @default.
- W2010919563 hasAuthorship W2010919563A5083420537 @default.
- W2010919563 hasAuthorship W2010919563A5091070290 @default.
- W2010919563 hasConcept C104317684 @default.
- W2010919563 hasConcept C111599444 @default.
- W2010919563 hasConcept C121608353 @default.
- W2010919563 hasConcept C126322002 @default.
- W2010919563 hasConcept C142724271 @default.
- W2010919563 hasConcept C147447768 @default.
- W2010919563 hasConcept C150903083 @default.
- W2010919563 hasConcept C170493617 @default.
- W2010919563 hasConcept C203014093 @default.
- W2010919563 hasConcept C204232928 @default.
- W2010919563 hasConcept C207001950 @default.
- W2010919563 hasConcept C2775960820 @default.
- W2010919563 hasConcept C2779013556 @default.
- W2010919563 hasConcept C2780559512 @default.
- W2010919563 hasConcept C2780631158 @default.
- W2010919563 hasConcept C2911091166 @default.
- W2010919563 hasConcept C502942594 @default.
- W2010919563 hasConcept C55493867 @default.
- W2010919563 hasConcept C57074206 @default.
- W2010919563 hasConcept C62478195 @default.
- W2010919563 hasConcept C71924100 @default.
- W2010919563 hasConcept C76419328 @default.
- W2010919563 hasConcept C86803240 @default.
- W2010919563 hasConcept C95444343 @default.