Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010933135> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2010933135 endingPage "69" @default.
- W2010933135 startingPage "63" @default.
- W2010933135 abstract "Abstract In this work the in-situ perfused rat liver has been used to examine the effect of changing the protein content of the perfusate on the hepatic extraction of O-acyl esters of salicylic acid. The hepatic availability (F) of these solutes was studied at a flow-rate of 30 mL min−1 with perfusate albumin concentrations of 0, 2, and 4% w/v. The hepatic availability of the esters was shown to decrease with increasing carbon-chain length in the O-acyl group; for all the esters the hepatic availability increased with increasing albumin concentration in the perfusate. The dispersion-model-derived efficiency number (RN) of the esters was shown to increase with increasing lipophilicity and decrease with increasing albumin concentration in the perfusate. The unbound fraction (fu) of the esters decreased with lipophilicity. RN/fu for acetylsalicylic acid remained relatively constant as the albumin concentration was increased. However, RN/fu for n-pentanoyl-and n-hexanoylsalicylic acids increased significantly as albumin concentration increased from 0% to 4%. Thus, for the more lipophilic solutes (n-pentanoyl- and n-hexanoylsalicylic acids) the presence of albumin apparently facilitates the uptake of unbound solute relative to acetylsalicylic acid." @default.
- W2010933135 created "2016-06-24" @default.
- W2010933135 creator A5011078693 @default.
- W2010933135 creator A5043993570 @default.
- W2010933135 creator A5064284123 @default.
- W2010933135 creator A5071943888 @default.
- W2010933135 date "1998-01-01" @default.
- W2010933135 modified "2023-09-29" @default.
- W2010933135 title "The Effect of Protein Binding on the Hepatic First Pass of <i>O</i>-Acyl Salicylate Derivatives in the Rat" @default.
- W2010933135 cites W1489376146 @default.
- W2010933135 cites W1834182974 @default.
- W2010933135 cites W1972683398 @default.
- W2010933135 cites W1973350537 @default.
- W2010933135 cites W1980750730 @default.
- W2010933135 cites W1992016040 @default.
- W2010933135 cites W2006637301 @default.
- W2010933135 cites W2008278365 @default.
- W2010933135 cites W2014178729 @default.
- W2010933135 cites W2032485613 @default.
- W2010933135 cites W2041791869 @default.
- W2010933135 cites W2059656737 @default.
- W2010933135 cites W2059973305 @default.
- W2010933135 cites W2060626333 @default.
- W2010933135 cites W2091669446 @default.
- W2010933135 cites W2115786883 @default.
- W2010933135 cites W2417543449 @default.
- W2010933135 cites W2463546333 @default.
- W2010933135 doi "https://doi.org/10.1111/j.2042-7158.1998.tb03306.x" @default.
- W2010933135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9504436" @default.
- W2010933135 hasPublicationYear "1998" @default.
- W2010933135 type Work @default.
- W2010933135 sameAs 2010933135 @default.
- W2010933135 citedByCount "6" @default.
- W2010933135 countsByYear W20109331352019 @default.
- W2010933135 crossrefType "journal-article" @default.
- W2010933135 hasAuthorship W2010933135A5011078693 @default.
- W2010933135 hasAuthorship W2010933135A5043993570 @default.
- W2010933135 hasAuthorship W2010933135A5064284123 @default.
- W2010933135 hasAuthorship W2010933135A5071943888 @default.
- W2010933135 hasBestOaLocation W20109331351 @default.
- W2010933135 hasConcept C165616093 @default.
- W2010933135 hasConcept C185592680 @default.
- W2010933135 hasConcept C201399114 @default.
- W2010933135 hasConcept C2776125364 @default.
- W2010933135 hasConcept C2778221352 @default.
- W2010933135 hasConcept C43617362 @default.
- W2010933135 hasConcept C55493867 @default.
- W2010933135 hasConceptScore W2010933135C165616093 @default.
- W2010933135 hasConceptScore W2010933135C185592680 @default.
- W2010933135 hasConceptScore W2010933135C201399114 @default.
- W2010933135 hasConceptScore W2010933135C2776125364 @default.
- W2010933135 hasConceptScore W2010933135C2778221352 @default.
- W2010933135 hasConceptScore W2010933135C43617362 @default.
- W2010933135 hasConceptScore W2010933135C55493867 @default.
- W2010933135 hasIssue "1" @default.
- W2010933135 hasLocation W20109331351 @default.
- W2010933135 hasLocation W20109331352 @default.
- W2010933135 hasOpenAccess W2010933135 @default.
- W2010933135 hasPrimaryLocation W20109331351 @default.
- W2010933135 hasRelatedWork W1974232315 @default.
- W2010933135 hasRelatedWork W1977201010 @default.
- W2010933135 hasRelatedWork W1990349658 @default.
- W2010933135 hasRelatedWork W2010933135 @default.
- W2010933135 hasRelatedWork W2036859676 @default.
- W2010933135 hasRelatedWork W2061648402 @default.
- W2010933135 hasRelatedWork W2515023988 @default.
- W2010933135 hasRelatedWork W2951554764 @default.
- W2010933135 hasRelatedWork W2952617904 @default.
- W2010933135 hasRelatedWork W2969695797 @default.
- W2010933135 hasVolume "50" @default.
- W2010933135 isParatext "false" @default.
- W2010933135 isRetracted "false" @default.
- W2010933135 magId "2010933135" @default.
- W2010933135 workType "article" @default.