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- W2010934539 endingPage "19" @default.
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- W2010934539 abstract "Type 1 diabetes mellitus (T1DM) is an autoimmune disease, where destruction of beta-cells causes insulin deficiency. The incidence of T1DM has increased in the last decades and cannot entirely be explained by genetic predisposition. Several environmental factors are suggested to promote T1DM, like early childhood enteroviral infections and nutritional factors, but the evidence is inconclusive. Prenatal and early life exposure to environmental pollutants like phthalates, bisphenol A, perfluorinated compounds, PCBs, dioxins, toxicants, and air pollutants can have negative effects on the developing immune system, resulting in asthma-like symptoms and increased susceptibility to childhood infections. In this review the associations between environmental chemical exposure and T1DM development is summarized. Although information on environmental chemicals as possible triggers for T1DM is sparse, we conclude that it is plausible that environmental chemicals can contribute to T1DM development via impaired pancreatic beta-cell and immune-cell functions and immunomodulation. Several environmental factors and chemicals could act together to trigger T1DM development in genetically susceptible individuals, possibly via hormonal or epigenetic alterations. Further observational T1DM cohort studies and animal exposure experiments are encouraged." @default.
- W2010934539 created "2016-06-24" @default.
- W2010934539 creator A5020830126 @default.
- W2010934539 creator A5058016891 @default.
- W2010934539 creator A5079039649 @default.
- W2010934539 date "2015-01-01" @default.
- W2010934539 modified "2023-10-17" @default.
- W2010934539 title "Can Exposure to Environmental Chemicals Increase the Risk of Diabetes Type 1 Development?" @default.
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