FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010936418> ?p ?o ?g. }

• W2010936418 endingPage "383" @default.
• W2010936418 startingPage "376" @default.
• W2010936418 abstract "Background: Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, has pleiotropic effects that are anti-inflammatory and antiatherothrombotic. It is important to understand the cardioprotective effects of rosuvastatin in order to optimize its additional advantages in the treatment and prevention of cardiovascular diseases. Methods: Human umbilical vein endothelial cells (HUVEC) were treated with tumor necrosis factor (TNF)-α (10 ng/mL) alone or with rosuvastatin (100 μM). The extent of inflammation was determined by U937 adhesion assay as well as analysis of the expression of intercellular adhesion molecule (ICAM)-1, monocyte chemoattractant protein (MCP)-1, interleukin (IL)-8, IL-6, cyclooxygenase (COX)-2, c-Jun N-terminal kinase (JNK), extracellular signal-regulated protein kinase (ERK), p38, and signal transducer and activator of transcription (STAT)-3. The activation of nuclear factor kappa B (NF-κB) was determined by Western blot. Results: Rosuvastatin decreased the extent of U937 adhesion to TNF-α-stimulated HUVEC. Rosuvastatin inhibited the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels. The activation of JNK and NF-κB was also blocked by rosuvastatin. The inhibitors of JNK, NF-κB, and STAT-3 produced a statistically significant decrease of the TNF-α induced U937 adhesion and IL-6 protein release. Conclusions: This study suggests that the anti-inflammatory activity of rosuvastatin is accompanied by the inhibition of JNK and NF-κB." @default.
• W2010936418 created "2016-06-24" @default.
• W2010936418 creator A5013429451 @default.
• W2010936418 creator A5022139851 @default.
• W2010936418 creator A5024282773 @default.
• W2010936418 creator A5035456738 @default.
• W2010936418 creator A5038699850 @default.
• W2010936418 creator A5048695610 @default.
• W2010936418 creator A5052825841 @default.
• W2010936418 creator A5053728368 @default.
• W2010936418 creator A5073229549 @default.
• W2010936418 creator A5074893722 @default.
• W2010936418 creator A5075329848 @default.
• W2010936418 creator A5079142386 @default.
• W2010936418 date "2007-06-01" @default.
• W2010936418 modified "2023-10-15" @default.
• W2010936418 title "Rosuvastatin Suppresses the Inflammatory Responses Through Inhibition of c-Jun N-terminal Kinase and Nuclear Factor-κB in Endothelial Cells" @default.
• W2010936418 cites W1479880028 @default.
• W2010936418 cites W1574813722 @default.
• W2010936418 cites W1965772617 @default.
• W2010936418 cites W1967980722 @default.
• W2010936418 cites W1970106273 @default.
• W2010936418 cites W1973523151 @default.
• W2010936418 cites W1977830503 @default.
• W2010936418 cites W1992997011 @default.
• W2010936418 cites W2002228737 @default.
• W2010936418 cites W2007129673 @default.
• W2010936418 cites W2012105257 @default.
• W2010936418 cites W2021303401 @default.
• W2010936418 cites W2023535764 @default.
• W2010936418 cites W2029378285 @default.
• W2010936418 cites W2037313852 @default.
• W2010936418 cites W2059118408 @default.
• W2010936418 cites W2066994466 @default.
• W2010936418 cites W2070044720 @default.
• W2010936418 cites W2074499846 @default.
• W2010936418 cites W2098683031 @default.
• W2010936418 cites W2109120190 @default.
• W2010936418 cites W2114845119 @default.
• W2010936418 cites W2131245007 @default.
• W2010936418 cites W2324841714 @default.
• W2010936418 cites W2408534315 @default.
• W2010936418 cites W4240527990 @default.
• W2010936418 cites W4256475235 @default.
• W2010936418 doi "https://doi.org/10.1097/fjc.0b013e31804a5e34" @default.
• W2010936418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17577102" @default.
• W2010936418 hasPublicationYear "2007" @default.
• W2010936418 type Work @default.
• W2010936418 sameAs 2010936418 @default.
• W2010936418 citedByCount "69" @default.
• W2010936418 countsByYear W20109364182012 @default.
• W2010936418 countsByYear W20109364182013 @default.
• W2010936418 countsByYear W20109364182014 @default.
• W2010936418 countsByYear W20109364182015 @default.
• W2010936418 countsByYear W20109364182016 @default.
• W2010936418 countsByYear W20109364182017 @default.
• W2010936418 countsByYear W20109364182018 @default.
• W2010936418 countsByYear W20109364182019 @default.
• W2010936418 countsByYear W20109364182020 @default.
• W2010936418 countsByYear W20109364182021 @default.
• W2010936418 countsByYear W20109364182022 @default.
• W2010936418 countsByYear W20109364182023 @default.
• W2010936418 crossrefType "journal-article" @default.
• W2010936418 hasAuthorship W2010936418A5013429451 @default.
• W2010936418 hasAuthorship W2010936418A5022139851 @default.
• W2010936418 hasAuthorship W2010936418A5024282773 @default.
• W2010936418 hasAuthorship W2010936418A5035456738 @default.
• W2010936418 hasAuthorship W2010936418A5038699850 @default.
• W2010936418 hasAuthorship W2010936418A5048695610 @default.
• W2010936418 hasAuthorship W2010936418A5052825841 @default.
• W2010936418 hasAuthorship W2010936418A5053728368 @default.
• W2010936418 hasAuthorship W2010936418A5073229549 @default.
• W2010936418 hasAuthorship W2010936418A5074893722 @default.
• W2010936418 hasAuthorship W2010936418A5075329848 @default.
• W2010936418 hasAuthorship W2010936418A5079142386 @default.
• W2010936418 hasBestOaLocation W20109364181 @default.
• W2010936418 hasConcept C108634530 @default.
• W2010936418 hasConcept C126322002 @default.
• W2010936418 hasConcept C17991360 @default.
• W2010936418 hasConcept C184235292 @default.
• W2010936418 hasConcept C185592680 @default.
• W2010936418 hasConcept C190283241 @default.
• W2010936418 hasConcept C2780499067 @default.
• W2010936418 hasConcept C2908737378 @default.
• W2010936418 hasConcept C51551487 @default.
• W2010936418 hasConcept C55493867 @default.
• W2010936418 hasConcept C57074206 @default.
• W2010936418 hasConcept C71924100 @default.
• W2010936418 hasConcept C98274493 @default.
• W2010936418 hasConceptScore W2010936418C108634530 @default.
• W2010936418 hasConceptScore W2010936418C126322002 @default.
• W2010936418 hasConceptScore W2010936418C17991360 @default.
• W2010936418 hasConceptScore W2010936418C184235292 @default.
• W2010936418 hasConceptScore W2010936418C185592680 @default.
• W2010936418 hasConceptScore W2010936418C190283241 @default.
• W2010936418 hasConceptScore W2010936418C2780499067 @default.
• W2010936418 hasConceptScore W2010936418C2908737378 @default.
• W2010936418 hasConceptScore W2010936418C51551487 @default.

• next