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- W2010948478 abstract "IN Neptunea antiqua the salivary glands are large organs weighing 1–3 gm. (Fig. 1). The fresh glands have a peculiar intense smell, probably due to the presence of volatile amines. Extracts of the glands (made with water, acetone or ethanol) have a strong contracting effect on smooth muscle. When a dose corresponding to about 1 : 100 of a gland was injected into small fishes (Ctenolabrus, Gadus) or mice, the animals died within a few minutes. When somewhat smaller doses were injected intraperitoneally into mice, the animals survived but developed symptoms of heavy stimulation of the parasympathetic system : a profuse secretion of saliva and tears. The secretion could be abolished by atropine. Glandular extracts were tested on the heart of Cyprina 1 or the isolated radula-muscle of Buccinum 2 and were found to produce acetylcholine-like effects corresponding to a concentration of acetylcholine of about 10−5 gm./ml. Unlike acetylcholine solutions the extracts did not lose their physiological effects by short boiling at pH 9 or by the addition of acetylcholine esterase (a drop of human blood). Paper chromatography showed a very distinct spot which was stained brickred by dipicrylamine3 and had an R F-value between choline and acetylcholine. Sometimes it was difficult to distinguish this spot from a spot produced by choline. The spot could also be identified by exposure to iodine vapours or by pharmacological testing of strips of the filter paper." @default.
- W2010948478 created "2016-06-24" @default.
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- W2010948478 date "1957-07-01" @default.
- W2010948478 modified "2023-10-16" @default.
- W2010948478 title "An Acetylcholine-like Salivary Poison in the Marine Gastropod Neptunea antiqua" @default.
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- W2010948478 doi "https://doi.org/10.1038/180196a0" @default.
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