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• W2010960667 abstract "The abnormally dark color of the gastrocnemius muscle in C57B16J dy-2J dystrophic mice is due, at least in part, to the increase in oxidative capacity of the fast-twitch fibers found in the crown of the diseased muscle. These fibers show an increased succinic dehydrogenase activity compared to normal crown fibers, and contain a higher mitochondrial volume percent compared to normal fibers using quantitative electron microscopy. They also show an abnormal amount of spontaneous activity in the form of a peripherally derived pseudomyotonia. Increased fiber activity and artifical stimulation of muscle fibers are known to cause an increase in oxidative capacity of mammalian skeletal muscle fibers. It is clear from the quantitative microscopy data, that although these fibers show an increase in mitochondrial volume and a concomitant increase in Z-disk thickness, they do not resemble the underlying oxidative fibers in either parameter. Furthermore, their ATPase activities show fast-twitch characteristics. The fibers in the crown of the dystrophic muscle do not result from fast-twitch glycolytic fiber degeneration leaving only the underlying oxidative fibers as occurs in the mouse dy mutation. The hypothesis is presented that the overactivity endured by these fibers may be the cause of their increased oxidative capacity." @default.
• W2010960667 created "2016-06-24" @default.
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• W2010960667 date "1980-04-01" @default.
• W2010960667 modified "2023-10-15" @default.
• W2010960667 title "Increase in oxidative capacity of muscle fibers in dystrophic mice and correlation with overactivity in these fibers" @default.
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• W2010960667 doi "https://doi.org/10.1016/0014-4886(80)90069-2" @default.
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