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• W2010965902 abstract "The dynamics of infectious diseases spread via direct person-to-person transmission (such as influenza, smallpox, HIV/AIDS, etc.) depends on the underlying host contact network. Human contact networks exhibit strong community structure. Understanding how such community structure affects epidemics may provide insights for preventing the spread of disease between communities by changing the structure of the contact network through pharmaceutical or non-pharmaceutical interventions. We use empirical and simulated networks to investigate the spread of disease in networks with community structure. We find that community structure has a major impact on disease dynamics, and we show that in networks with strong community structure, immunization interventions targeted at individuals bridging communities are more effective than those simply targeting highly connected individuals. Because the structure of relevant contact networks is generally not known, and vaccine supply is often limited, there is great need for efficient vaccination algorithms that do not require full knowledge of the network. We developed an algorithm that acts only on locally available network information and is able to quickly identify targets for successful immunization intervention. The algorithm generally outperforms existing algorithms when vaccine supply is limited, particularly in networks with strong community structure. Understanding the spread of infectious diseases and designing optimal control strategies is a major goal of public health. Social networks show marked patterns of community structure, and our results, based on empirical and simulated data, demonstrate that community structure strongly affects disease dynamics. These results have implications for the design of control strategies." @default.
• W2010965902 created "2016-06-24" @default.
• W2010965902 creator A5010649096 @default.
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• W2010965902 date "2010-04-08" @default.
• W2010965902 modified "2023-10-16" @default.
• W2010965902 title "Dynamics and Control of Diseases in Networks with Community Structure" @default.
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• W2010965902 doi "https://doi.org/10.1371/journal.pcbi.1000736" @default.
• W2010965902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2851561" @default.
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