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• W2010971607 abstract "T-cell exhaustion has become an important issue in chronic infection because exhausted antigen-specific T cells show impaired abilities to eradicate persistently infected pathogens and produce effector cytokines, such as IFN-γ and TNF-α. Thus, strategies to either restore endogenous exhausted T cell responses or provide functional T cells are needed for therapeutics of chronic infection. Despite promising developments using antibodies and cell immunotherapy, there have been no reported attempts to restore exhausted T cells using treatment with materials derived from natural resources. Here, using a mouse model of chronic infection with lymphocytic choriomeningitis virus (LCMV), we found that vinegar-processed flowers (flos) of Daphne genkwa (vp-genkwa), which was composed mainly of four index components, restored exhausted CD4+ and CD8+ T cells significantly, as corroborated by evidence that vp-genkwa treatment enhanced functional LCMV-specific CD4+ and CD8+ T cells, both quantitatively and qualitatively. Furthermore, pretreatment with vp-genkwa prevented the generation of exhausted LCMV-specific CD8+ T cells. Such restorations of exhausted LCMV-specific CD4+ and CD8+ T cells by vp-genkwa were closely associated with reduced viral burden in sera and tissues. More interestingly, vp-genkwa treatment induced down-regulation of negative molecules, such as PD-1 and Tim-3, in exhausted CD4+ and CD8+ T cells with more apparent down-regulation of Tim-3, suggesting that Tim-3 molecule may be a major target in restoring exhausted T cell responses. Collectively, these results provide valuable new insights into the use of vp-genkwa to develop a therapeutic strategy for chronic human diseases, such as hepatitis B and C virus, human immunodeficiency virus, and cancers." @default.
• W2010971607 created "2016-06-24" @default.
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• W2010971607 date "2015-04-01" @default.
• W2010971607 modified "2023-09-25" @default.
• W2010971607 title "Functional restoration of exhausted CD4+ and CD8+ T cells in chronic viral infection by vinegar-processed flos of Daphne genkwa" @default.
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• W2010971607 doi "https://doi.org/10.1016/j.cimid.2015.02.001" @default.
• W2010971607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25744061" @default.
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