FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010981300> ?p ?o ?g. }

• W2010981300 endingPage "1688" @default.
• W2010981300 startingPage "1680" @default.
• W2010981300 abstract "The relationship between blood ethanol concentration and hepatic ethanol metabolism commonly is calculated using the Michaelis-Menten equation and a one-compartment model that assumes equality of blood and hepatic ethanol concentrations. However, at low blood concentrations, most of the ethanol arriving at the liver is metabolized, and hepatic ethanol concentrations may fall far below that of the entering blood. We have developed a two-compartment model of ethanol metabolism that accounts for the fall in ethanol concentration that may occur as blood traverses the liver and used this model to make predictions concerning ethanol metabolism at various blood ethanol concentrations. The two-compartment model predicts that near-complete saturation will occur more abruptly and at a lower blood concentration (approximately 3 mM) than is the case with the one-compartment model. Thus, the two-compartment model predicts a near-constant ethanol elimination rate for blood ethanol concentrations above 3 mM (as commonly observed in human subjects), whereas the one-compartment model predicts an increasing elimination rate over the range of concentrations observed in experimental studies. In agreement with observed data, the two-compartment model predicts that first-pass metabolism should be extremely sensitive to the rate of ethanol absorption. Application of this model to previously published data indicated that, when absorption was slowed via concomitant food ingestion, first-pass metabolism accounts for approximately 50% and 10% of ethanol dosages of 0.15 g/kg and 0.3 g/kg, respectively. When ingested without food, there is negligible first-pass metabolism of even very small ethanol dosages (0.15 g/kg). These findings suggest that first-pass metabolism is an unimportant determinant of the blood ethanol response to ingestion of potentially inebriating doses of ethanol." @default.
• W2010981300 created "2016-06-24" @default.
• W2010981300 creator A5048218266 @default.
• W2010981300 creator A5080784173 @default.
• W2010981300 date "1998-11-01" @default.
• W2010981300 modified "2023-10-16" @default.
• W2010981300 title "Use of a Two-Compartment Model to Assess the Pharmacokinetics of Human Ethanol Metabolism" @default.
• W2010981300 cites W1923205770 @default.
• W2010981300 cites W1979322079 @default.
• W2010981300 cites W1985790178 @default.
• W2010981300 cites W2051572903 @default.
• W2010981300 cites W2074468139 @default.
• W2010981300 cites W2076317193 @default.
• W2010981300 cites W2089934061 @default.
• W2010981300 cites W2119294396 @default.
• W2010981300 cites W2131630482 @default.
• W2010981300 cites W2395688276 @default.
• W2010981300 cites W2399287373 @default.
• W2010981300 cites W2410507923 @default.
• W2010981300 cites W2955761657 @default.
• W2010981300 cites W4229721039 @default.
• W2010981300 cites W4239602802 @default.
• W2010981300 cites W4253825873 @default.
• W2010981300 doi "https://doi.org/10.1111/j.1530-0277.1998.tb03966.x" @default.
• W2010981300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9835281" @default.
• W2010981300 hasPublicationYear "1998" @default.
• W2010981300 type Work @default.
• W2010981300 sameAs 2010981300 @default.
• W2010981300 citedByCount "32" @default.
• W2010981300 countsByYear W20109813002012 @default.
• W2010981300 countsByYear W20109813002013 @default.
• W2010981300 countsByYear W20109813002014 @default.
• W2010981300 countsByYear W20109813002016 @default.
• W2010981300 countsByYear W20109813002018 @default.
• W2010981300 countsByYear W20109813002019 @default.
• W2010981300 countsByYear W20109813002020 @default.
• W2010981300 countsByYear W20109813002021 @default.
• W2010981300 countsByYear W20109813002023 @default.
• W2010981300 crossrefType "journal-article" @default.
• W2010981300 hasAuthorship W2010981300A5048218266 @default.
• W2010981300 hasAuthorship W2010981300A5080784173 @default.
• W2010981300 hasConcept C111368507 @default.
• W2010981300 hasConcept C112705442 @default.
• W2010981300 hasConcept C121332964 @default.
• W2010981300 hasConcept C125287762 @default.
• W2010981300 hasConcept C127313418 @default.
• W2010981300 hasConcept C147789679 @default.
• W2010981300 hasConcept C185592680 @default.
• W2010981300 hasConcept C195289149 @default.
• W2010981300 hasConcept C201253974 @default.
• W2010981300 hasConcept C203635412 @default.
• W2010981300 hasConcept C24890656 @default.
• W2010981300 hasConcept C2780161600 @default.
• W2010981300 hasConcept C30153976 @default.
• W2010981300 hasConcept C55493867 @default.
• W2010981300 hasConcept C62231903 @default.
• W2010981300 hasConcept C8171440 @default.
• W2010981300 hasConcept C86803240 @default.
• W2010981300 hasConcept C89311334 @default.
• W2010981300 hasConcept C98274493 @default.
• W2010981300 hasConceptScore W2010981300C111368507 @default.
• W2010981300 hasConceptScore W2010981300C112705442 @default.
• W2010981300 hasConceptScore W2010981300C121332964 @default.
• W2010981300 hasConceptScore W2010981300C125287762 @default.
• W2010981300 hasConceptScore W2010981300C127313418 @default.
• W2010981300 hasConceptScore W2010981300C147789679 @default.
• W2010981300 hasConceptScore W2010981300C185592680 @default.
• W2010981300 hasConceptScore W2010981300C195289149 @default.
• W2010981300 hasConceptScore W2010981300C201253974 @default.
• W2010981300 hasConceptScore W2010981300C203635412 @default.
• W2010981300 hasConceptScore W2010981300C24890656 @default.
• W2010981300 hasConceptScore W2010981300C2780161600 @default.
• W2010981300 hasConceptScore W2010981300C30153976 @default.
• W2010981300 hasConceptScore W2010981300C55493867 @default.
• W2010981300 hasConceptScore W2010981300C62231903 @default.
• W2010981300 hasConceptScore W2010981300C8171440 @default.
• W2010981300 hasConceptScore W2010981300C86803240 @default.
• W2010981300 hasConceptScore W2010981300C89311334 @default.
• W2010981300 hasConceptScore W2010981300C98274493 @default.
• W2010981300 hasIssue "8" @default.
• W2010981300 hasLocation W20109813001 @default.
• W2010981300 hasLocation W20109813002 @default.
• W2010981300 hasOpenAccess W2010981300 @default.
• W2010981300 hasPrimaryLocation W20109813001 @default.
• W2010981300 hasRelatedWork W1721799416 @default.
• W2010981300 hasRelatedWork W2010981300 @default.
• W2010981300 hasRelatedWork W2032864369 @default.
• W2010981300 hasRelatedWork W2055223893 @default.
• W2010981300 hasRelatedWork W2116410331 @default.
• W2010981300 hasRelatedWork W2207332422 @default.
• W2010981300 hasRelatedWork W2244507257 @default.
• W2010981300 hasRelatedWork W2245636290 @default.
• W2010981300 hasRelatedWork W4233091365 @default.
• W2010981300 hasRelatedWork W55360940 @default.
• W2010981300 hasVolume "22" @default.
• W2010981300 isParatext "false" @default.
• W2010981300 isRetracted "false" @default.
• W2010981300 magId "2010981300" @default.

• next