FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010992494> ?p ?o ?g. }

• W2010992494 endingPage "931" @default.
• W2010992494 startingPage "919" @default.
• W2010992494 abstract "The study of proteins from extremophilic organisms continues to generate interest in the field of protein folding because paradigms explaining the enhanced stability of these proteins still elude us and such studies have the potential to further our knowledge of the forces stabilizing proteins. We have undertaken such a study with our model protein HPr from a mesophile, Bacillus subtilis, and a thermophile, Bacillus stearothermophilus. We report here the high-resolution structures of the wild-type HPr protein from the thermophile and a variant, F29W. The variant proved to crystallize in two forms: a monomeric form with a structure very similar to the wild-type protein as well as a domain-swapped dimer. Interestingly, the structure of the domain-swapped dimer for HPr is very different from that observed for a homologous protein, Crh, from B.subtilis. The existence of a domain-swapped dimer has implications for amyloid formation and is consistent with recent results showing that the HPr proteins can form amyloid fibrils. We also characterized the conformational stability of the thermophilic HPr proteins using thermal and solvent denaturation methods and have used the high-resolution structures in an attempt to explain the differences in stability between the different HPr proteins. Finally, we present a detailed analysis of the solution properties of the HPr proteins using a variety of biochemical and biophysical methods." @default.
• W2010992494 created "2016-06-24" @default.
• W2010992494 creator A5055128383 @default.
• W2010992494 creator A5062257527 @default.
• W2010992494 creator A5076751721 @default.
• W2010992494 creator A5087375751 @default.
• W2010992494 date "2005-02-01" @default.
• W2010992494 modified "2023-10-12" @default.
• W2010992494 title "The HPr Proteins from the Thermophile Bacillus stearothermophilus can form Domain-swapped Dimers" @default.
• W2010992494 cites W1539796472 @default.
• W2010992494 cites W1587687959 @default.
• W2010992494 cites W1590313270 @default.
• W2010992494 cites W1591864042 @default.
• W2010992494 cites W1860073488 @default.
• W2010992494 cites W1970232844 @default.
• W2010992494 cites W1971306922 @default.
• W2010992494 cites W1978963526 @default.
• W2010992494 cites W1984748839 @default.
• W2010992494 cites W2000934302 @default.
• W2010992494 cites W2001641653 @default.
• W2010992494 cites W2002095965 @default.
• W2010992494 cites W2005914057 @default.
• W2010992494 cites W2009857351 @default.
• W2010992494 cites W2015642465 @default.
• W2010992494 cites W2023444769 @default.
• W2010992494 cites W2025929456 @default.
• W2010992494 cites W2027115739 @default.
• W2010992494 cites W2027304997 @default.
• W2010992494 cites W2040874305 @default.
• W2010992494 cites W2056103246 @default.
• W2010992494 cites W2056525187 @default.
• W2010992494 cites W2060276346 @default.
• W2010992494 cites W2060809301 @default.
• W2010992494 cites W2067411283 @default.
• W2010992494 cites W2070184351 @default.
• W2010992494 cites W2078652488 @default.
• W2010992494 cites W2083368946 @default.
• W2010992494 cites W2088776290 @default.
• W2010992494 cites W2089618587 @default.
• W2010992494 cites W2093185451 @default.
• W2010992494 cites W2103598875 @default.
• W2010992494 cites W2106882534 @default.
• W2010992494 cites W2117747873 @default.
• W2010992494 cites W2123887137 @default.
• W2010992494 cites W2132717858 @default.
• W2010992494 cites W2135839939 @default.
• W2010992494 cites W2136567909 @default.
• W2010992494 cites W2147283838 @default.
• W2010992494 cites W2160082320 @default.
• W2010992494 cites W2160982787 @default.
• W2010992494 cites W2161731881 @default.
• W2010992494 cites W2342448023 @default.
• W2010992494 cites W2916078022 @default.
• W2010992494 doi "https://doi.org/10.1016/j.jmb.2004.12.008" @default.
• W2010992494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15713472" @default.
• W2010992494 hasPublicationYear "2005" @default.
• W2010992494 type Work @default.
• W2010992494 sameAs 2010992494 @default.
• W2010992494 citedByCount "14" @default.
• W2010992494 countsByYear W20109924942012 @default.
• W2010992494 countsByYear W20109924942013 @default.
• W2010992494 countsByYear W20109924942020 @default.
• W2010992494 countsByYear W20109924942023 @default.
• W2010992494 crossrefType "journal-article" @default.
• W2010992494 hasAuthorship W2010992494A5055128383 @default.
• W2010992494 hasAuthorship W2010992494A5062257527 @default.
• W2010992494 hasAuthorship W2010992494A5076751721 @default.
• W2010992494 hasAuthorship W2010992494A5087375751 @default.
• W2010992494 hasConcept C104317684 @default.
• W2010992494 hasConcept C12554922 @default.
• W2010992494 hasConcept C136238340 @default.
• W2010992494 hasConcept C144292202 @default.
• W2010992494 hasConcept C178790620 @default.
• W2010992494 hasConcept C181199279 @default.
• W2010992494 hasConcept C185592680 @default.
• W2010992494 hasConcept C204328495 @default.
• W2010992494 hasConcept C2777272437 @default.
• W2010992494 hasConcept C2779546866 @default.
• W2010992494 hasConcept C27911776 @default.
• W2010992494 hasConcept C2909197731 @default.
• W2010992494 hasConcept C47701112 @default.
• W2010992494 hasConcept C523546767 @default.
• W2010992494 hasConcept C54355233 @default.
• W2010992494 hasConcept C55493867 @default.
• W2010992494 hasConcept C8010536 @default.
• W2010992494 hasConcept C86803240 @default.
• W2010992494 hasConceptScore W2010992494C104317684 @default.
• W2010992494 hasConceptScore W2010992494C12554922 @default.
• W2010992494 hasConceptScore W2010992494C136238340 @default.
• W2010992494 hasConceptScore W2010992494C144292202 @default.
• W2010992494 hasConceptScore W2010992494C178790620 @default.
• W2010992494 hasConceptScore W2010992494C181199279 @default.
• W2010992494 hasConceptScore W2010992494C185592680 @default.
• W2010992494 hasConceptScore W2010992494C204328495 @default.
• W2010992494 hasConceptScore W2010992494C2777272437 @default.
• W2010992494 hasConceptScore W2010992494C2779546866 @default.
• W2010992494 hasConceptScore W2010992494C27911776 @default.
• W2010992494 hasConceptScore W2010992494C2909197731 @default.

• next