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- W2010993054 abstract "Compounds that exhibit a covalent mechanism of action are typically avoided in drug discovery programmes, largely owing to safety concerns. Here, Singh and colleagues present the pharmacological advantages offered by covalent drugs and discuss strategies to address the potential risks and challenges that have been associated with these agents. Covalent drugs haveproved to be successful therapies for various indications, but largely owing to safety concerns, they are rarely considered when initiating a target-directed drug discovery project. There is a need to reassess this important class of drugs, and to reconcile the discordance between the historic success of covalent drugs and the reluctance of most drug discovery teams to include them in their armamentarium. This Review surveys the prevalence and pharmacological advantages of covalent drugs, discusses how potential risks and challenges may be addressed through innovative design, and presents the broad opportunities provided by targeted covalent inhibitors." @default.
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- W2010993054 date "2011-04-01" @default.
- W2010993054 modified "2023-10-09" @default.
- W2010993054 title "The resurgence of covalent drugs" @default.
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- W2010993054 doi "https://doi.org/10.1038/nrd3410" @default.
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