FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010993315> ?p ?o ?g. }

• W2010993315 endingPage "11" @default.
• W2010993315 startingPage "6" @default.
• W2010993315 abstract "Hsp90 (Heat shock protein-90) is a cellular buffer against erroneous gene products and also plays an essential role in facilitating proper folding, maturation, and activity of its client proteins. The phosphatidylinositol-3 kinase (PI-3K)–Akt pathway transduces a survival signal involved in tumor development. The kinase activity of Akt depends on its association with Hsp90. Hsp90 inhibition causes Akt degradation, but the mechanism remains unclear. Several reports showed that the Hsp90 inhibitor geldanamycin (GA) induces Thr308 and Ser473 phosphorylations of Akt, however, it is still unknown about the significance of GA-induced Akt activation in degradation of the kinase. We treated Hela cells with GA to observe Akt degradation and found that LY294002 delayed Akt degradation. Mutation of Thr308 or Ser473 also caused delayed Akt ubiquitination and degradation. Inhibition of Akt dephosphorylation enhanced GA-mediated Akt degradation. In this report, we show that GA-mediated transient activation of Akt accelerates its association with the E3 ligase CHIP (C-terminal Hsp70-interacting protein)-mediated ubiquitination and subsequent proteasome degradation." @default.
• W2010993315 created "2016-06-24" @default.
• W2010993315 creator A5003956817 @default.
• W2010993315 creator A5026090288 @default.
• W2010993315 creator A5035552947 @default.
• W2010993315 creator A5042673919 @default.
• W2010993315 creator A5054235677 @default.
• W2010993315 creator A5060481940 @default.
• W2010993315 creator A5077269939 @default.
• W2010993315 date "2013-08-01" @default.
• W2010993315 modified "2023-10-18" @default.
• W2010993315 title "Phosphorylation accelerates geldanamycin-induced Akt degradation" @default.
• W2010993315 cites W1554180547 @default.
• W2010993315 cites W1968332198 @default.
• W2010993315 cites W1976980728 @default.
• W2010993315 cites W1991158062 @default.
• W2010993315 cites W1992909271 @default.
• W2010993315 cites W1993218631 @default.
• W2010993315 cites W1999938778 @default.
• W2010993315 cites W2004792969 @default.
• W2010993315 cites W2043865307 @default.
• W2010993315 cites W2044304089 @default.
• W2010993315 cites W2047570827 @default.
• W2010993315 cites W2050621039 @default.
• W2010993315 cites W2074579328 @default.
• W2010993315 cites W2096540145 @default.
• W2010993315 cites W2097840941 @default.
• W2010993315 cites W2107442883 @default.
• W2010993315 cites W2126762966 @default.
• W2010993315 cites W2138821198 @default.
• W2010993315 cites W2146854995 @default.
• W2010993315 cites W2148902358 @default.
• W2010993315 cites W4240506612 @default.
• W2010993315 doi "https://doi.org/10.1016/j.abb.2013.04.015" @default.
• W2010993315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23668972" @default.
• W2010993315 hasPublicationYear "2013" @default.
• W2010993315 type Work @default.
• W2010993315 sameAs 2010993315 @default.
• W2010993315 citedByCount "15" @default.
• W2010993315 countsByYear W20109933152014 @default.
• W2010993315 countsByYear W20109933152015 @default.
• W2010993315 countsByYear W20109933152016 @default.
• W2010993315 countsByYear W20109933152018 @default.
• W2010993315 countsByYear W20109933152019 @default.
• W2010993315 countsByYear W20109933152022 @default.
• W2010993315 countsByYear W20109933152023 @default.
• W2010993315 crossrefType "journal-article" @default.
• W2010993315 hasAuthorship W2010993315A5003956817 @default.
• W2010993315 hasAuthorship W2010993315A5026090288 @default.
• W2010993315 hasAuthorship W2010993315A5035552947 @default.
• W2010993315 hasAuthorship W2010993315A5042673919 @default.
• W2010993315 hasAuthorship W2010993315A5054235677 @default.
• W2010993315 hasAuthorship W2010993315A5060481940 @default.
• W2010993315 hasAuthorship W2010993315A5077269939 @default.
• W2010993315 hasConcept C104317684 @default.
• W2010993315 hasConcept C11960822 @default.
• W2010993315 hasConcept C134459356 @default.
• W2010993315 hasConcept C185592680 @default.
• W2010993315 hasConcept C205260736 @default.
• W2010993315 hasConcept C25602115 @default.
• W2010993315 hasConcept C2775932338 @default.
• W2010993315 hasConcept C2776912716 @default.
• W2010993315 hasConcept C2780297055 @default.
• W2010993315 hasConcept C2992195973 @default.
• W2010993315 hasConcept C55493867 @default.
• W2010993315 hasConcept C62478195 @default.
• W2010993315 hasConcept C75217442 @default.
• W2010993315 hasConcept C86554907 @default.
• W2010993315 hasConcept C86803240 @default.
• W2010993315 hasConcept C95444343 @default.
• W2010993315 hasConceptScore W2010993315C104317684 @default.
• W2010993315 hasConceptScore W2010993315C11960822 @default.
• W2010993315 hasConceptScore W2010993315C134459356 @default.
• W2010993315 hasConceptScore W2010993315C185592680 @default.
• W2010993315 hasConceptScore W2010993315C205260736 @default.
• W2010993315 hasConceptScore W2010993315C25602115 @default.
• W2010993315 hasConceptScore W2010993315C2775932338 @default.
• W2010993315 hasConceptScore W2010993315C2776912716 @default.
• W2010993315 hasConceptScore W2010993315C2780297055 @default.
• W2010993315 hasConceptScore W2010993315C2992195973 @default.
• W2010993315 hasConceptScore W2010993315C55493867 @default.
• W2010993315 hasConceptScore W2010993315C62478195 @default.
• W2010993315 hasConceptScore W2010993315C75217442 @default.
• W2010993315 hasConceptScore W2010993315C86554907 @default.
• W2010993315 hasConceptScore W2010993315C86803240 @default.
• W2010993315 hasConceptScore W2010993315C95444343 @default.
• W2010993315 hasFunder F4320321040 @default.
• W2010993315 hasIssue "1" @default.
• W2010993315 hasLocation W20109933151 @default.
• W2010993315 hasLocation W20109933152 @default.
• W2010993315 hasOpenAccess W2010993315 @default.
• W2010993315 hasPrimaryLocation W20109933151 @default.
• W2010993315 hasRelatedWork W1969146047 @default.
• W2010993315 hasRelatedWork W1986242330 @default.
• W2010993315 hasRelatedWork W2011038682 @default.
• W2010993315 hasRelatedWork W2034987223 @default.
• W2010993315 hasRelatedWork W2055052888 @default.
• W2010993315 hasRelatedWork W2058641375 @default.

• next