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- W2011000316 abstract "Liver microsomal steroid 5-alpha-reduction is catalyzed by a NADPH-dependent enzyme system. The requirement of NADPH-cytochrome P-450 reductase to shuttle reduction equivalents from NADPH to steroid 5-alpha-reductase was investigated using an inhibitory antibody against NADPH-cytochrome P-450 reductase. This antibody preparation inhibited cytochrome c reduction in microsomes from female rat liver with an I50 of 0.75 mg antibody/mg of microsomal protein. Benzphetamine N-demethylation and testosterone 6-beta-hydroxylation, two cytochrome P-450-mediated oxidative reactions, were inhibited by the antibody. On the other hand, testosterone 5-alpha-reductase was not affected by the antibody. These results suggest that NADPH-cytochrome P-450 reductase is not an obligatory component of the liver microsomal steroid 5-alpha-reduction." @default.
- W2011000316 created "2016-06-24" @default.
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- W2011000316 date "1989-12-01" @default.
- W2011000316 modified "2023-09-26" @default.
- W2011000316 title "NADPH-cytochrome P-450 reductase is not a component of the liver microsomal steroid 5-alpha reductase" @default.
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- W2011000316 doi "https://doi.org/10.1016/s0006-291x(89)80007-5" @default.
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