Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011001489> ?p ?o ?g. }
- W2011001489 endingPage "2384" @default.
- W2011001489 startingPage "2379" @default.
- W2011001489 abstract "Conjugation of drugs with antibodies to surface endothelial antigens is a potential strategy for drug delivery to endothelium. We studied antibodies to platelet-endothelial adhesion molecule 1 (PECAM-1, a stably expressed endothelial antigen) as carriers for vascular immunotargeting. Although 125 I-labeled anti-PECAM bound to endothelial cells in culture, the antibody was poorly internalized by the cells and accumulated poorly after intravenous administration in mice and rats. However, conjugation of biotinylated anti-PECAM (b-anti-PECAM) with streptavidin (SA) markedly stimulated uptake and internalization of anti-PECAM by endothelial cells and by cells expressing PECAM. In addition, conjugation with streptavidin markedly stimulated uptake of 125 I-labeled b-anti-PECAM in perfused rat lungs and in the lungs of intact animals after either intravenous or intraarterial injection. The antioxidant enzyme catalase conjugated with b-anti-PECAM/SA bound to endothelial cells in culture, entered the cells, escaped intracellular degradation, and protected the cells against H 2 O 2 -induced injury. Anti-PECAM/SA/ 125 I-catalase accumulated in the lungs after intravenous injection or in the perfused rat lungs and protected these lungs against H 2 O 2 -induced injury. Thus, modification of a poor carrier antibody with biotin and SA provides an approach for facilitation of antibody-mediated drug targeting. Anti-PECAM/SA is a promising candidate for vascular immunotargeting of bioactive drugs." @default.
- W2011001489 created "2016-06-24" @default.
- W2011001489 creator A5005953721 @default.
- W2011001489 creator A5017021744 @default.
- W2011001489 creator A5022854559 @default.
- W2011001489 creator A5022924802 @default.
- W2011001489 creator A5025908399 @default.
- W2011001489 creator A5031076625 @default.
- W2011001489 creator A5053664038 @default.
- W2011001489 date "1999-03-02" @default.
- W2011001489 modified "2023-10-18" @default.
- W2011001489 title "Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): A strategy for vascular immunotargeting of drugs" @default.
- W2011001489 cites W150469298 @default.
- W2011001489 cites W1845807143 @default.
- W2011001489 cites W1900564117 @default.
- W2011001489 cites W1962538984 @default.
- W2011001489 cites W1964570763 @default.
- W2011001489 cites W1976658012 @default.
- W2011001489 cites W1982687474 @default.
- W2011001489 cites W1982942806 @default.
- W2011001489 cites W1993946853 @default.
- W2011001489 cites W1996499842 @default.
- W2011001489 cites W1996673454 @default.
- W2011001489 cites W2006548681 @default.
- W2011001489 cites W2037548392 @default.
- W2011001489 cites W2046046896 @default.
- W2011001489 cites W2049866297 @default.
- W2011001489 cites W2054197767 @default.
- W2011001489 cites W2060228717 @default.
- W2011001489 cites W2085882810 @default.
- W2011001489 cites W2090569473 @default.
- W2011001489 cites W2107241291 @default.
- W2011001489 cites W2125814580 @default.
- W2011001489 cites W2184443404 @default.
- W2011001489 cites W2405996794 @default.
- W2011001489 cites W413016067 @default.
- W2011001489 doi "https://doi.org/10.1073/pnas.96.5.2379" @default.
- W2011001489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/26792" @default.
- W2011001489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10051650" @default.
- W2011001489 hasPublicationYear "1999" @default.
- W2011001489 type Work @default.
- W2011001489 sameAs 2011001489 @default.
- W2011001489 citedByCount "128" @default.
- W2011001489 countsByYear W20110014892012 @default.
- W2011001489 countsByYear W20110014892013 @default.
- W2011001489 countsByYear W20110014892014 @default.
- W2011001489 countsByYear W20110014892015 @default.
- W2011001489 countsByYear W20110014892016 @default.
- W2011001489 countsByYear W20110014892017 @default.
- W2011001489 countsByYear W20110014892018 @default.
- W2011001489 countsByYear W20110014892019 @default.
- W2011001489 countsByYear W20110014892020 @default.
- W2011001489 countsByYear W20110014892021 @default.
- W2011001489 countsByYear W20110014892022 @default.
- W2011001489 countsByYear W20110014892023 @default.
- W2011001489 crossrefType "journal-article" @default.
- W2011001489 hasAuthorship W2011001489A5005953721 @default.
- W2011001489 hasAuthorship W2011001489A5017021744 @default.
- W2011001489 hasAuthorship W2011001489A5022854559 @default.
- W2011001489 hasAuthorship W2011001489A5022924802 @default.
- W2011001489 hasAuthorship W2011001489A5025908399 @default.
- W2011001489 hasAuthorship W2011001489A5031076625 @default.
- W2011001489 hasAuthorship W2011001489A5053664038 @default.
- W2011001489 hasBestOaLocation W20110014892 @default.
- W2011001489 hasConcept C123012128 @default.
- W2011001489 hasConcept C134018914 @default.
- W2011001489 hasConcept C139770010 @default.
- W2011001489 hasConcept C147483822 @default.
- W2011001489 hasConcept C1491633281 @default.
- W2011001489 hasConcept C153911025 @default.
- W2011001489 hasConcept C159654299 @default.
- W2011001489 hasConcept C185592680 @default.
- W2011001489 hasConcept C202751555 @default.
- W2011001489 hasConcept C203014093 @default.
- W2011001489 hasConcept C204628709 @default.
- W2011001489 hasConcept C2776992346 @default.
- W2011001489 hasConcept C55493867 @default.
- W2011001489 hasConcept C86803240 @default.
- W2011001489 hasConcept C95444343 @default.
- W2011001489 hasConceptScore W2011001489C123012128 @default.
- W2011001489 hasConceptScore W2011001489C134018914 @default.
- W2011001489 hasConceptScore W2011001489C139770010 @default.
- W2011001489 hasConceptScore W2011001489C147483822 @default.
- W2011001489 hasConceptScore W2011001489C1491633281 @default.
- W2011001489 hasConceptScore W2011001489C153911025 @default.
- W2011001489 hasConceptScore W2011001489C159654299 @default.
- W2011001489 hasConceptScore W2011001489C185592680 @default.
- W2011001489 hasConceptScore W2011001489C202751555 @default.
- W2011001489 hasConceptScore W2011001489C203014093 @default.
- W2011001489 hasConceptScore W2011001489C204628709 @default.
- W2011001489 hasConceptScore W2011001489C2776992346 @default.
- W2011001489 hasConceptScore W2011001489C55493867 @default.
- W2011001489 hasConceptScore W2011001489C86803240 @default.
- W2011001489 hasConceptScore W2011001489C95444343 @default.
- W2011001489 hasIssue "5" @default.
- W2011001489 hasLocation W20110014891 @default.
- W2011001489 hasLocation W20110014892 @default.
- W2011001489 hasLocation W20110014893 @default.