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- W2011007883 abstract "A test has been made of a stereochemical prediction for conjugate addition based on the intermediacy of d,π∗-complexes in the reaction of organocopper reagents with α,β-enones. The chiral α,β-enone 7 has been synthesized and subjected to reaction with various methyl cuprate reagents. Under conditions favorable to lithium chelation to the α-alkoxycarbonyl system of 7, conjugate addition to 7 was found to proceed with high (13:1 to 33:1) 1,4-diastereoselectivity, the configuration of the major diastereomer being that predicted by the d,π∗-complex model. A new and especially diastereoselective reagent has been generated by the reaction of LiCuMe2 with 0.3 equivalent of water, a possible structure for which is presented." @default.
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- W2011007883 modified "2023-10-16" @default.
- W2011007883 title "Coordinattvely induced 1,4-diastereoselection in the reaction of acyclic α,β-enones with organocopper reagents. A new type of organocopper reagent" @default.
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