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- W2011011237 abstract "It has been known for many years that free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), promote diseases such as cancer. Peroxiredoxins (Prdxs) are small H2O2 scavenging proteins that appear to have tumor preventive functions since loss of Prdx1 in mice leads to premature death from cancer. However, as Prdxs are antioxidants they also scavenge the H2O2 in cancer cells that way supporting survival and tumor maintenance. This suggests that Prdxs function as tumor ‘preventers’ rather than as tumor suppressors since they do not induce cell death when re-expressed in cancer cells, as it occurs with the tumor suppressor p53. Therefore, the knowledge of Prdx function and regulation may help provide a fuller understanding of the role of ROS in tumorigenesis." @default.
- W2011011237 created "2016-06-24" @default.
- W2011011237 creator A5042057264 @default.
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- W2011011237 date "2007-08-01" @default.
- W2011011237 modified "2023-10-14" @default.
- W2011011237 title "Are peroxiredoxins tumor suppressors?" @default.
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- W2011011237 doi "https://doi.org/10.1016/j.coph.2007.04.007" @default.
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