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- W2011014416 abstract "1. To clarify the effect of arginine vasotocin (AVT) on intracellular pH (pHi) of A6 cells (an amphibian renal cell line), we measured pHi with a single-cell fluorescent imaging system in an HCO3−nominally-free medium. 2. AVT (40mU/ml) significantly decreased pHi from 7.44 ± 0.11 to 7.19 ± 0.22 (mean ± SE) by inhibiting the Na+/H+ exchanger. 3. A membrane-permeable analogue of cAMP, dibutyryl cAMP (1mM), significantly decreased pHi from 7.40 ± 0.02 to 7.17 ± 0.02, a response similar to that of AVT. 4. These data indicate that, in A6 cells, AVT suppresses the Na+/H+ exchanger via a cAMP-dependent pathway and the Na+/H+ exchanger maintains pHi under HCO3−-nominally-free conditions." @default.
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- W2011014416 date "1995-07-01" @default.
- W2011014416 modified "2023-09-26" @default.
- W2011014416 title "Antidiuretic hormone decreases the intracellular pH in distal nephron epithelium (A6) by inhibiting Na+/H+ exchange" @default.
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- W2011014416 doi "https://doi.org/10.1016/0306-3623(94)00254-k" @default.
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