FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011015637> ?p ?o ?g. }

• W2011015637 endingPage "48" @default.
• W2011015637 startingPage "38" @default.
• W2011015637 abstract "Phorbol 12-myristate 13-acetate (PMA), a protein kinase C-activating phorbol ester, is known to inhibit chondrogenic differentiation by embryonic limb mesenchyme cells in vitro. The present study demonstrates that staurosporine, a potent inhibitor of protein kinase C, conversely stimulates cartilage differentiation in cultures of limb mesenchyme cells isolated from whole wing buds of stage 23/24 chick embryos or from the distal subridge region of stage 25 wing buds. In high density micromass cultures, in which limb mesenchyme cells undergo extensive spontaneous cartilage differentiation, exposure to 5–20 nM staurosporine promotes an accelerated accumulation o f type II collagen and cartilage proteoglycan mRNA transcripts and a 2- to 3-fold increase in matrix glycosaminoglycan deposition. Even in low density, monolayer cultures in which the mesenchymal cells do not normally form cartilage, treatment with 5 nM staurosporine induces extensive Alcian blue-positive matrix production, a striking 4- to 18-fold rise in sulfated glycosaminoglycan accumulation, and a dramatic elevation of cartilage-characteristic gene transcript expression. Moreover, concurrent treatment with staurosporine overcomes the inhibitory effects of PMA on in vitro limb cartilage differentiation. The results suggest the hypothesis that protein kinase C might function as a negative modulator of chondrogenic differentiation during embryonic limb development." @default.
• W2011015637 created "2016-06-24" @default.
• W2011015637 creator A5057178607 @default.
• W2011015637 date "1991-07-01" @default.
• W2011015637 modified "2023-09-25" @default.
• W2011015637 title "Promotion of embryonic limb cartilage differentiation in vitro by staurosporine, a protein kinase C inhibitor" @default.
• W2011015637 cites W1498226262 @default.
• W2011015637 cites W1589866689 @default.
• W2011015637 cites W1594758412 @default.
• W2011015637 cites W1964839077 @default.
• W2011015637 cites W1967375014 @default.
• W2011015637 cites W1973740712 @default.
• W2011015637 cites W1978127297 @default.
• W2011015637 cites W1982635439 @default.
• W2011015637 cites W1992626881 @default.
• W2011015637 cites W1998183746 @default.
• W2011015637 cites W2002468752 @default.
• W2011015637 cites W2005096820 @default.
• W2011015637 cites W2017786515 @default.
• W2011015637 cites W2021148581 @default.
• W2011015637 cites W2036663611 @default.
• W2011015637 cites W2036832507 @default.
• W2011015637 cites W2037256734 @default.
• W2011015637 cites W2039636049 @default.
• W2011015637 cites W2042320391 @default.
• W2011015637 cites W2047952382 @default.
• W2011015637 cites W2050338578 @default.
• W2011015637 cites W2053073736 @default.
• W2011015637 cites W2070520484 @default.
• W2011015637 cites W2070841221 @default.
• W2011015637 cites W2075617106 @default.
• W2011015637 cites W2078250644 @default.
• W2011015637 cites W2087309480 @default.
• W2011015637 cites W2090564168 @default.
• W2011015637 cites W2134072927 @default.
• W2011015637 cites W2138094668 @default.
• W2011015637 cites W2140034535 @default.
• W2011015637 cites W2171958561 @default.
• W2011015637 cites W2174520807 @default.
• W2011015637 doi "https://doi.org/10.1016/0012-1606(91)90444-8" @default.
• W2011015637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2060709" @default.
• W2011015637 hasPublicationYear "1991" @default.
• W2011015637 type Work @default.
• W2011015637 sameAs 2011015637 @default.
• W2011015637 citedByCount "35" @default.
• W2011015637 countsByYear W20110156372014 @default.
• W2011015637 countsByYear W20110156372015 @default.
• W2011015637 countsByYear W20110156372020 @default.
• W2011015637 crossrefType "journal-article" @default.
• W2011015637 hasAuthorship W2011015637A5057178607 @default.
• W2011015637 hasConcept C104317684 @default.
• W2011015637 hasConcept C105702510 @default.
• W2011015637 hasConcept C145103041 @default.
• W2011015637 hasConcept C148738053 @default.
• W2011015637 hasConcept C153911025 @default.
• W2011015637 hasConcept C184235292 @default.
• W2011015637 hasConcept C195794163 @default.
• W2011015637 hasConcept C196843134 @default.
• W2011015637 hasConcept C25770073 @default.
• W2011015637 hasConcept C2776340970 @default.
• W2011015637 hasConcept C2779084600 @default.
• W2011015637 hasConcept C2780550940 @default.
• W2011015637 hasConcept C35496256 @default.
• W2011015637 hasConcept C55493867 @default.
• W2011015637 hasConcept C86370654 @default.
• W2011015637 hasConcept C86803240 @default.
• W2011015637 hasConcept C95444343 @default.
• W2011015637 hasConcept C97029542 @default.
• W2011015637 hasConceptScore W2011015637C104317684 @default.
• W2011015637 hasConceptScore W2011015637C105702510 @default.
• W2011015637 hasConceptScore W2011015637C145103041 @default.
• W2011015637 hasConceptScore W2011015637C148738053 @default.
• W2011015637 hasConceptScore W2011015637C153911025 @default.
• W2011015637 hasConceptScore W2011015637C184235292 @default.
• W2011015637 hasConceptScore W2011015637C195794163 @default.
• W2011015637 hasConceptScore W2011015637C196843134 @default.
• W2011015637 hasConceptScore W2011015637C25770073 @default.
• W2011015637 hasConceptScore W2011015637C2776340970 @default.
• W2011015637 hasConceptScore W2011015637C2779084600 @default.
• W2011015637 hasConceptScore W2011015637C2780550940 @default.
• W2011015637 hasConceptScore W2011015637C35496256 @default.
• W2011015637 hasConceptScore W2011015637C55493867 @default.
• W2011015637 hasConceptScore W2011015637C86370654 @default.
• W2011015637 hasConceptScore W2011015637C86803240 @default.
• W2011015637 hasConceptScore W2011015637C95444343 @default.
• W2011015637 hasConceptScore W2011015637C97029542 @default.
• W2011015637 hasIssue "1" @default.
• W2011015637 hasLocation W20110156371 @default.
• W2011015637 hasLocation W20110156372 @default.
• W2011015637 hasOpenAccess W2011015637 @default.
• W2011015637 hasPrimaryLocation W20110156371 @default.
• W2011015637 hasRelatedWork W1238323808 @default.
• W2011015637 hasRelatedWork W1865792554 @default.
• W2011015637 hasRelatedWork W1973710655 @default.
• W2011015637 hasRelatedWork W1981270313 @default.
• W2011015637 hasRelatedWork W2003367516 @default.
• W2011015637 hasRelatedWork W2021283509 @default.
• W2011015637 hasRelatedWork W2046482635 @default.

• next