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• W2011016507 abstract "Letters4 April 2000Congenital C2 (Type I) Deficiency Associated with Common Variable ImmunodeficiencyMaria Elena Soto, MD, Fernando Cordera, MD, and Pedro A. Reyes, MDMaria Elena Soto, MDInstituto Nacional de Cardiología Ignacio Chávez; Mexico D.F., Mexico 14080 (Soto)Instituto Nacional de Cardiología Ignacio Chávez; Mexico D.F., Mexico 14080 (Cordera)Instituto Nacional de Cardiología Ignacio Chávez; Mexico D.F., Mexico 14080 (Reyes)Search for more papers by this author, Fernando Cordera, MDInstituto Nacional de Cardiología Ignacio Chávez; Mexico D.F., Mexico 14080 (Soto)Instituto Nacional de Cardiología Ignacio Chávez; Mexico D.F., Mexico 14080 (Cordera)Instituto Nacional de Cardiología Ignacio Chávez; Mexico D.F., Mexico 14080 (Reyes)Search for more papers by this author, and Pedro A. Reyes, MDInstituto Nacional de Cardiología Ignacio Chávez; Mexico D.F., Mexico 14080 (Soto)Instituto Nacional de Cardiología Ignacio Chávez; Mexico D.F., Mexico 14080 (Cordera)Instituto Nacional de Cardiología Ignacio Chávez; Mexico D.F., Mexico 14080 (Reyes)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-7-200004040-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:C2 deficiency associated with common variable immunodeficiency is rare (1-3). We report another case of this association.Our patient, whose mother was diabetic, had received full immunization and had normal psychomotor development. At 3 years of age, she presented with thrombocytopenia; at 9, 12, and 15 years of age, she developed pneumonia; and at 15 years of age, purulent peritonitis and pericardial effusion occurred. Three years later, she developed pneumonia again, and at age 19 she experienced repeated chest pain that prompted referral to our hospital.Ischemic heart disease, pulmonary hypertension, cystic fibrosis, and tuberculosis were excluded. ...References1. Seligmann M, Brouet JC, Sasportes M. Hereditary C2 deficiency associated with common variable immunodeficiency. Ann Intern Med. 1979;91:216-7. LinkGoogle Scholar2. Arala-Chaves MP, Fudenberg HH, Boackle RJ, Ainsworth SK, Mello-Vieira R. A case of “common variable immunodeficiency” with reduced C2 activity and multiple associations. Clin Immunol Immunopathol. 1980;17:227-34. CrossrefMedlineGoogle Scholar3. Sanal O, Yel L, Tezcan I, Ersoy F, Berkel AI. Homozygous C2 deficiency: association with defective alternative pathway function and immunoglobulin deficiency. Int Arch Allergy Immunol. 1996;110:195-8. CrossrefMedlineGoogle Scholar4. Melin-Aldana H, Reyes PA, Vargas-Alarcon G, Yamamoto-Furusho , Granados J. Mayor histocompatibility complex genes in a Mexican family with deficiency of the second component of the complement system. Rev Invest Clin. 1996;48:307-9. MedlineGoogle Scholar5. Nonoyama S, Farrongton M, Ishida H, Howard M, Ochs HD. Activated B cells from patients with common variable immunodeficiency proliferate and synthesize immunoglobulin. J Clin Invest. 1993;92:1282-7. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Instituto Nacional de Cardiología Ignacio Chávez; Mexico D.F., Mexico 14080 (Soto)Instituto Nacional de Cardiología Ignacio Chávez; Mexico D.F., Mexico 14080 (Cordera)Instituto Nacional de Cardiología Ignacio Chávez; Mexico D.F., Mexico 14080 (Reyes) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLevothyroxine Interactions with Food and Dietary Supplements–A Systematic ReviewMannose-binding lectin polymorphisms in common variable immunodeficiencyCommon variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis 4 April 2000Volume 132, Issue 7Page: 597KeywordsAntibodiesCellsImmunodeficienciesKneesLymphocytesPeritonitisPneumoniaProteinsPulmonary hypertensionUpper respiratory tract infections Issue Published: 4 April 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ..." @default.
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