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• W2011022219 startingPage "63" @default.
• W2011022219 abstract "The roles of regulatory T cells (Tregs) and PD-1 in hepatitis B have not been clearly described. Also, the role of B and T lymphocyte attenuator (BTLA), which serves as a negative regulator of T-cell activation, is still unknown in hepatitis B. In this study, we analyzed the frequency of circulating CD4+CD25high Tregs in patients with chronic hepatitis B (CHB), and subsequently investigated expression of PD-1 and BTLA on CD4+ T cells, as well as their relationships with the clinical index of CHB patients. A total of 39 CHB patients and 19 healthy persons as controls were enrolled in the study. We found that the frequency of CD4+CD25high Tregs and PD-1 expression on CD4+ T cells was significantly increased in CHB patients compared with normal controls. However, BTLA expression on CD4+ T cells showed no significant difference between the two groups. The frequency of Tregs was significantly higher in patients with HBV DNA titers ≥108 than in those with HBV DNA titers <108. Circulating CD4+CD25high Treg frequency and PD-1 expression on CD4+ T cells correlated positively with serum HBV DNA load in CHB patients. Our findings suggest that the increased frequency of CD4+CD25high Tregs and PD-1 expression on CD4+ T lymphocytes may inhibit the cellular immune response against HBV and affect viral clearance, leading to the persistence of chronic HBV infection." @default.
• W2011022219 created "2016-06-24" @default.
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• W2011022219 date "2010-02-01" @default.
• W2011022219 modified "2023-10-18" @default.
• W2011022219 title "Circulating CD4⁺CD25^highRegulatory T Cells and Expression of PD-1 and BTLA on CD4⁺T Cells in Patients with Chronic Hepatitis B Virus Infection" @default.
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• W2011022219 doi "https://doi.org/10.1089/vim.2009.0061" @default.
• W2011022219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20121403" @default.
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