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• W2011024176 abstract "Although the effects of the interleukin 13 (IL-13) on goblet cell (GC) hyperplasia have been studied in the gut and respiratory tracts, its effect on regulating conjunctival GC has not been explored. The purpose of this study was to determine the major IL-13-producing cell type and the role of IL-13 in GC homeostasis in normal murine conjunctiva. Using isolating techniques, we identified natural killer (NK)/natural killer T (NKT) cells as the main producers of IL-13. We also observed that IL-13 knockout (KO) and signal transducer and activator of transcription 6 knockout (STAT6KO) mice had a lower number of periodic acid Schiff (PAS)+GCs. We observed that desiccating stress (DS) decreases NK population, GCs, and IL-13, whereas it increases interferon-γ (IFN-γ) mRNA in conjunctiva. Cyclosporine A treatment during DS maintained the number of NK/NKT cells in the conjunctiva, increased IL-13 mRNA in NK+ cells, and decreased IFN-γ and IL-17A mRNA transcripts in NK+ and NK− populations. C57BL/6 mice chronically depleted of NK/NKT cells, as well as NKT cell-deficient RAG1KO and CD1dKO mice, had fewer filled GCs than their wild-type counterparts. NK depletion in CD1dKO mice had no further effect on the number of PAS+ cells. Taken together, these findings indicate that NKT cells are major sources of IL-13 in the conjunctival mucosa that regulates GC homeostasis." @default.
• W2011024176 created "2016-06-24" @default.
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• W2011024176 date "2011-07-01" @default.
• W2011024176 modified "2023-10-16" @default.
• W2011024176 title "Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13" @default.
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• W2011024176 cites W1523354060 @default.
• W2011024176 cites W1548938800 @default.
• W2011024176 cites W1554313978 @default.
• W2011024176 cites W1557018067 @default.
• W2011024176 cites W1560116787 @default.
• W2011024176 cites W1583226605 @default.
• W2011024176 cites W1585378175 @default.
• W2011024176 cites W180054770 @default.
• W2011024176 cites W1857016869 @default.
• W2011024176 cites W1887031720 @default.
• W2011024176 cites W1968320501 @default.
• W2011024176 cites W1970348725 @default.
• W2011024176 cites W1979323310 @default.
• W2011024176 cites W1981288386 @default.
• W2011024176 cites W1985954206 @default.
• W2011024176 cites W1989137861 @default.
• W2011024176 cites W1990994365 @default.
• W2011024176 cites W1992576863 @default.
• W2011024176 cites W1997352945 @default.
• W2011024176 cites W1997452530 @default.
• W2011024176 cites W2001682689 @default.
• W2011024176 cites W2002180108 @default.
• W2011024176 cites W2008975391 @default.
• W2011024176 cites W2012344956 @default.
• W2011024176 cites W2017297281 @default.
• W2011024176 cites W2022210343 @default.
• W2011024176 cites W2023865177 @default.
• W2011024176 cites W2027944849 @default.
• W2011024176 cites W2029860358 @default.
• W2011024176 cites W2033076789 @default.
• W2011024176 cites W2036806857 @default.
• W2011024176 cites W2037393831 @default.
• W2011024176 cites W2039663324 @default.
• W2011024176 cites W2043644170 @default.
• W2011024176 cites W2043764313 @default.
• W2011024176 cites W2046968511 @default.
• W2011024176 cites W2049207532 @default.
• W2011024176 cites W2050258939 @default.
• W2011024176 cites W2050337641 @default.
• W2011024176 cites W2054013327 @default.
• W2011024176 cites W2060763719 @default.
• W2011024176 cites W2062744636 @default.
• W2011024176 cites W2070122182 @default.
• W2011024176 cites W2070695825 @default.
• W2011024176 cites W2073808197 @default.
• W2011024176 cites W2074357311 @default.
• W2011024176 cites W2078202405 @default.
• W2011024176 cites W2080556279 @default.
• W2011024176 cites W2080882265 @default.
• W2011024176 cites W2092100225 @default.
• W2011024176 cites W2092844155 @default.
• W2011024176 cites W2098727982 @default.
• W2011024176 cites W2108786544 @default.
• W2011024176 cites W2112495824 @default.
• W2011024176 cites W2112797831 @default.
• W2011024176 cites W2112942968 @default.
• W2011024176 cites W2114087849 @default.
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• W2011024176 cites W2121360614 @default.
• W2011024176 cites W2124600315 @default.
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• W2011024176 cites W2147516175 @default.
• W2011024176 cites W2153028610 @default.
• W2011024176 cites W2169195499 @default.
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• W2011024176 doi "https://doi.org/10.1038/mi.2010.82" @default.
• W2011024176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3577073" @default.
• W2011024176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21178983" @default.
• W2011024176 hasPublicationYear "2011" @default.
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