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- W2011025503 abstract "Following closely in the wake of the discovery that cancer of the skin can be produced experimentally by the repeated application of tar, attempts have been made, through the years, to induce cancer in practically all of the other body organs. It may be said, that, as a general rule, where a potent tar can be applied repeatedly, or where a sufficient quantity of it can be placed so as to remain immobile for a sufficient length of time, cancer may be induced in a varyingly high percentage of instances. There are regions, however, that tend to defy the experimenter. Among such locations are the lungs. The physical difficulty of applying tar directly to the lung structures is apparent and requires no explanation. The difficulties in the way of making repeated direct applications of tar to the same lung are even more obvious. A survey of the literature shows that the earliest experimental attack on the problem of experimental tar cancer of the lung was made by Murphy and Sturm (1), who noted that when mice were tarred in various skin areas they developed primary tumors of the lung. In one of their groups of mice these investigators observed a 78.3 per cent incidence of primary lung tumors in tarred animals, though no tumors occurred in a control series. Murphy and Sturm designate these lung tumors as “a distinct type of epithelial tumor” and furnish reasons for believing that they are primary neoplasms. Care was taken to kill the animals early enough in life to avoid the possible complicating factor of primary lung tumors incident to age rather than to tar. The authors furnish no dogmatic explanation for the development of the tumors, but they strongly incline to the belief that the tar painting has the constitutional effect of lowering the resistance of the animals, and that local irritation (caused by inhaled particles of shavings, sawdust and chopped food), grafted on the lowered resistance, induces pulmonary tumor formation" @default.
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- W2011025503 date "1938-08-01" @default.
- W2011025503 modified "2023-09-27" @default.
- W2011025503 title "The Production of Experimental Cancer of the Lung in Mice" @default.
- W2011025503 doi "https://doi.org/10.1158/ajc.1938.549a" @default.
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