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- W2011027013 abstract "Biomedical implants often exhibit poor clinical performance due to the formation of a periimplant avascular fibrous capsule. Surface modification of synthetic materials has been evaluated to accelerate the formation of functional microcirculation in association with implants. The current study used a flow-mediated protein deposition system to modify expanded polytetrafluoroethylene (ePTFE) with a laminin-5-rich conditioned growth medium and with medium from which laminin-5 had been selectively removed. An in vitro model of endothelial cell adherence determined that laminin-5 modification resulted in significantly increased adhesion of human microvessel endothelial cells to ePTFE. In vivo studies evaluating the periimplant vascular response to laminin-5-treated samples indicated that absorption of laminin-5-rich conditioned medium supported accelerated neovascularization of ePTFE implants. A flow system designed to treat porous implant materials facilitates laminin-5 modification of commercially available ePTFE, resulting in increased endothelial cell adhesion in vitro and increased vascularization in vivo." @default.
- W2011027013 created "2016-06-24" @default.
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- W2011027013 date "2005-09-01" @default.
- W2011027013 modified "2023-09-26" @default.
- W2011027013 title "Stimulated Endothelial Cell Adhesion and Angiogenesis with Laminin-5 Modification of Expanded Polytetrafluoroethylene" @default.
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- W2011027013 doi "https://doi.org/10.1089/ten.2005.11.1379" @default.
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