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• W2011028864 abstract "The embryonic kidney is a classic developmental model system for studying inductive tissue interactions that govern organogenesis. We report here that Wnt-6 is expressed in the ureter bud, and that cell lines expressing Wnt-6 induce nephrogenesis in vitro. Wnt-6 cells induce tubules with similar kinetics to spinal cord (SPC) and lead to induced expression of Pax2, Pax8, Sfrp2, and E-cadherin genes, early markers of tubulogenesis. Moreover, Wnt-6 signaling rescues tubulogenesis in mesenchyme separated from Wnt-4 mutant embryos and leads to activation of Wnt-4 transcription. Wnt-6 also induces a secondary axis in early Xenopus embryos. We conclude that Wnt-6 is a candidate for the ureter epithelium-derived signal that leads to activation of kidney tubulogenesis via Wnt-4." @default.
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• W2011028864 date "2002-03-18" @default.
• W2011028864 modified "2023-10-18" @default.
• W2011028864 title "Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro" @default.
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• W2011028864 doi "https://doi.org/10.1002/gene.10079" @default.
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