FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011031607> ?p ?o ?g. }

• W2011031607 endingPage "2583" @default.
• W2011031607 startingPage "2577" @default.
• W2011031607 abstract "Tyrosine phosphorylation is an early step in lipopolysaccharide (LPS) stimulated monocytes and macrophages that appears to play a key role in signal transduction. We have demonstrated that LPS purified from Actinobacillus actinomycetemcomitans also increases protein tyrosine phosphorylation in human gingival fibroblasts (HGF). This effect was elicited rapidly after LPS stimulation at concentrations that stimulate anti-bacterial responses in human gingival fibroblasts. Two main proteins, with an apparent molecular weight of 44 and 42 kDa, were phosphorylated after LPS stimulation of the human gingival fibroblasts. The phosphorylation was detected after 5 to 15 min and reached the maximum at 30 min of treatment. The increase in tyrosine phosphorylation was apparent following stimulation with LPS at 10 ng/ml and the response was dose dependent up to 10 μg/ml. Pretreatment with the tyrosine kinase inhibitors, herbimycin A and genistein inhibited the LPS-stimulated phosphorylation of p44 and p42 MAP kinases in a dose dependent manner. Pretreatment of human gingival fibroblasts with antibodies anti-CD14 or anti-TLR-4 but not anti-TLR-2 inhibited the LPS-induced tyrosine phosphorylation of p44 and p42. Additionally, LPS-induced p44 and p42 phosphorylation was inhibited by polymyxin treatment. These findings demonstrate that LPS from A. actinomycetemcomintans increases rapidly p44 and p42 phosphorylation (ERK 1 and ERK 2, respectively) in human gingival fibroblasts. Our data also suggest that CD14 and TLR-4 receptors are involved in the LPS effects in human gingival fibroblasts." @default.
• W2011031607 created "2016-06-24" @default.
• W2011031607 creator A5008271063 @default.
• W2011031607 creator A5013810926 @default.
• W2011031607 creator A5022905584 @default.
• W2011031607 creator A5061176328 @default.
• W2011031607 creator A5089616591 @default.
• W2011031607 date "2006-04-01" @default.
• W2011031607 modified "2023-10-02" @default.
• W2011031607 title "Actinobacillus actinomycetemcomitans lipopolysaccharide stimulates the phosphorylation of p44 and p42 MAP kinases through CD14 and TLR-4 receptor activation in human gingival fibroblasts" @default.
• W2011031607 cites W1524870960 @default.
• W2011031607 cites W1568165627 @default.
• W2011031607 cites W1671728707 @default.
• W2011031607 cites W1766658148 @default.
• W2011031607 cites W1877846554 @default.
• W2011031607 cites W1899566673 @default.
• W2011031607 cites W1900704206 @default.
• W2011031607 cites W1964394075 @default.
• W2011031607 cites W1965971815 @default.
• W2011031607 cites W1975414790 @default.
• W2011031607 cites W2010297897 @default.
• W2011031607 cites W2027152576 @default.
• W2011031607 cites W2027729467 @default.
• W2011031607 cites W2029157767 @default.
• W2011031607 cites W2032589830 @default.
• W2011031607 cites W2039088937 @default.
• W2011031607 cites W2043644048 @default.
• W2011031607 cites W2044959710 @default.
• W2011031607 cites W2065840972 @default.
• W2011031607 cites W2067294390 @default.
• W2011031607 cites W2083076387 @default.
• W2011031607 cites W2091415746 @default.
• W2011031607 cites W2095833996 @default.
• W2011031607 cites W2097971686 @default.
• W2011031607 cites W2105785789 @default.
• W2011031607 cites W2109350206 @default.
• W2011031607 cites W2113225558 @default.
• W2011031607 cites W2125133469 @default.
• W2011031607 cites W2138964534 @default.
• W2011031607 cites W2146746046 @default.
• W2011031607 cites W2152096613 @default.
• W2011031607 cites W2164454317 @default.
• W2011031607 cites W2164701257 @default.
• W2011031607 cites W4248900035 @default.
• W2011031607 doi "https://doi.org/10.1016/j.lfs.2005.10.033" @default.
• W2011031607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16318859" @default.
• W2011031607 hasPublicationYear "2006" @default.
• W2011031607 type Work @default.
• W2011031607 sameAs 2011031607 @default.
• W2011031607 citedByCount "26" @default.
• W2011031607 countsByYear W20110316072012 @default.
• W2011031607 countsByYear W20110316072013 @default.
• W2011031607 countsByYear W20110316072014 @default.
• W2011031607 countsByYear W20110316072015 @default.
• W2011031607 countsByYear W20110316072018 @default.
• W2011031607 crossrefType "journal-article" @default.
• W2011031607 hasAuthorship W2011031607A5008271063 @default.
• W2011031607 hasAuthorship W2011031607A5013810926 @default.
• W2011031607 hasAuthorship W2011031607A5022905584 @default.
• W2011031607 hasAuthorship W2011031607A5061176328 @default.
• W2011031607 hasAuthorship W2011031607A5089616591 @default.
• W2011031607 hasConcept C101544691 @default.
• W2011031607 hasConcept C11960822 @default.
• W2011031607 hasConcept C126322002 @default.
• W2011031607 hasConcept C132149769 @default.
• W2011031607 hasConcept C134018914 @default.
• W2011031607 hasConcept C153911025 @default.
• W2011031607 hasConcept C170493617 @default.
• W2011031607 hasConcept C184235292 @default.
• W2011031607 hasConcept C185592680 @default.
• W2011031607 hasConcept C24998067 @default.
• W2011031607 hasConcept C2777553839 @default.
• W2011031607 hasConcept C2778513237 @default.
• W2011031607 hasConcept C2778754761 @default.
• W2011031607 hasConcept C42362537 @default.
• W2011031607 hasConcept C55493867 @default.
• W2011031607 hasConcept C57074206 @default.
• W2011031607 hasConcept C62478195 @default.
• W2011031607 hasConcept C71924100 @default.
• W2011031607 hasConcept C85528070 @default.
• W2011031607 hasConcept C86803240 @default.
• W2011031607 hasConcept C95444343 @default.
• W2011031607 hasConceptScore W2011031607C101544691 @default.
• W2011031607 hasConceptScore W2011031607C11960822 @default.
• W2011031607 hasConceptScore W2011031607C126322002 @default.
• W2011031607 hasConceptScore W2011031607C132149769 @default.
• W2011031607 hasConceptScore W2011031607C134018914 @default.
• W2011031607 hasConceptScore W2011031607C153911025 @default.
• W2011031607 hasConceptScore W2011031607C170493617 @default.
• W2011031607 hasConceptScore W2011031607C184235292 @default.
• W2011031607 hasConceptScore W2011031607C185592680 @default.
• W2011031607 hasConceptScore W2011031607C24998067 @default.
• W2011031607 hasConceptScore W2011031607C2777553839 @default.
• W2011031607 hasConceptScore W2011031607C2778513237 @default.
• W2011031607 hasConceptScore W2011031607C2778754761 @default.
• W2011031607 hasConceptScore W2011031607C42362537 @default.
• W2011031607 hasConceptScore W2011031607C55493867 @default.
• W2011031607 hasConceptScore W2011031607C57074206 @default.

• next