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- W2011032274 abstract "The effect of 6-mercaptopurine on the development and expression of delayed hypersensitivity was studied in the guinea pig. Results indicated that 6-MP produced its suppressive effects primarily by action on cells of the monocyte-macrophage series. Suppression could occur under conditions of both developing and pre-established delayed hypersensitivity. The defect primarily involved newly synthesized, bone marrow-derived monocytes. Marked alterations in monocyte-macrophage generation and distribution, especially the T12 of circulating monocytes were demonstrated. Suppressive effects were associated with the appearance of a unique morphologic defect in the macrophage, that of nuclear cytoplasmic asynchrony, demonstrated by electron microscopy. Finally, the in vivo expression of delayed hypersensitivity correlated better with a variety of parameters relating to qualitative macrophage function and distribution rather than those relating to quantitative macrophage levels." @default.
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- W2011032274 date "1979-07-01" @default.
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- W2011032274 title "Mechanisms in the suppression of delayed hypersensitivity in the guinea pig by 6-mercaptopurine. II: Kinetic and morphologic studies on the monocyte-macrophage component" @default.
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- W2011032274 doi "https://doi.org/10.1016/0162-3109(79)90026-2" @default.
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