Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011035878> ?p ?o ?g. }
- W2011035878 endingPage "59" @default.
- W2011035878 startingPage "29" @default.
- W2011035878 abstract "Tuberoinfundibular peptide of 39 residues (TIP39) is the recently purified endogenous ligand of the previously orphan G-protein coupled parathyroid hormone 2 receptor (PTH2R). The TIP39–PTH2R system is a unique neuropeptide–receptor system whose localization and functions in the central nervous system are different from any other neuropeptides. TIP39 is expressed in two brain regions, the subparafascicular area in the posterior thalamus, and the medial paralemniscal nucleus in the lateral pons. Subparafascicular TIP39 neurons seem to divide into a medial and a lateral cell population in the periventricular gray of the thalamus, and in the posterior intralaminar complex of the thalamus, respectively. Periventricular thalamic TIP39 neurons project mostly to limbic brain regions, the posterior intralaminar thalamic TIP39 neurons to neuroendocrine brain areas, and the medial paralemniscal TIP39 neurons to auditory and other brainstem regions, and the spinal cord. The widely distributed axon terminals of TIP39 neurons have a similar distribution as the PTH2R-containing neurons, and their fibers, providing the anatomical basis of a neuromodulatory action of TIP39. Initial functional studies implicated the TIP39–PTH2R system in nociceptive information processing in the spinal cord, in the regulation of different hypophysiotropic neurons in the hypothalamus, and in the modulation of affective behaviors. Recently developed novel experimental tools including mice with targeted mutations of the TIP39–PTH2R system and specific antagonists of the PTH2R will further facilitate the identification of the specific roles of TIP39 and the PTH2R." @default.
- W2011035878 created "2016-06-24" @default.
- W2011035878 creator A5060835610 @default.
- W2011035878 creator A5073787062 @default.
- W2011035878 creator A5084703314 @default.
- W2011035878 date "2010-01-11" @default.
- W2011035878 modified "2023-10-03" @default.
- W2011035878 title "The TIP39–PTH2 receptor system: Unique peptidergic cell groups in the brainstem and their interactions with central regulatory mechanisms" @default.
- W2011035878 cites W103628247 @default.
- W2011035878 cites W112700550 @default.
- W2011035878 cites W136606487 @default.
- W2011035878 cites W149103117 @default.
- W2011035878 cites W1494469291 @default.
- W2011035878 cites W1495437191 @default.
- W2011035878 cites W1509868652 @default.
- W2011035878 cites W1513763202 @default.
- W2011035878 cites W1522048223 @default.
- W2011035878 cites W1532998256 @default.
- W2011035878 cites W1537685381 @default.
- W2011035878 cites W1542467604 @default.
- W2011035878 cites W154630843 @default.
- W2011035878 cites W1554082519 @default.
- W2011035878 cites W1575171254 @default.
- W2011035878 cites W1576236928 @default.
- W2011035878 cites W1794801390 @default.
- W2011035878 cites W1829722206 @default.
- W2011035878 cites W1909104250 @default.
- W2011035878 cites W1963616810 @default.
- W2011035878 cites W1964538581 @default.
- W2011035878 cites W1964838294 @default.
- W2011035878 cites W1964950298 @default.
- W2011035878 cites W1966101477 @default.
- W2011035878 cites W1966591888 @default.
- W2011035878 cites W1968093456 @default.
- W2011035878 cites W1968267226 @default.
- W2011035878 cites W1968502398 @default.
- W2011035878 cites W1968530473 @default.
- W2011035878 cites W1968541451 @default.
- W2011035878 cites W1968956946 @default.
- W2011035878 cites W1969080702 @default.
- W2011035878 cites W1969636390 @default.
- W2011035878 cites W1972343360 @default.
- W2011035878 cites W1973771822 @default.
- W2011035878 cites W1975190631 @default.
- W2011035878 cites W1975756729 @default.
- W2011035878 cites W1976898002 @default.
- W2011035878 cites W1976909984 @default.
- W2011035878 cites W1977470259 @default.
- W2011035878 cites W1977934229 @default.
- W2011035878 cites W1978755010 @default.
- W2011035878 cites W1978900877 @default.
- W2011035878 cites W1981137788 @default.
- W2011035878 cites W1981568012 @default.
- W2011035878 cites W1982770740 @default.
- W2011035878 cites W1983119903 @default.
- W2011035878 cites W1983140003 @default.
- W2011035878 cites W1983511521 @default.
- W2011035878 cites W1986363785 @default.
- W2011035878 cites W1986444444 @default.
- W2011035878 cites W1986755975 @default.
- W2011035878 cites W1987364373 @default.
- W2011035878 cites W1987375466 @default.
- W2011035878 cites W1989456694 @default.
- W2011035878 cites W1989873691 @default.
- W2011035878 cites W1990523428 @default.
- W2011035878 cites W1991103268 @default.
- W2011035878 cites W1991556400 @default.
- W2011035878 cites W1992021880 @default.
- W2011035878 cites W1994784656 @default.
- W2011035878 cites W1995713067 @default.
- W2011035878 cites W1996643687 @default.
- W2011035878 cites W1997330635 @default.
- W2011035878 cites W1997916401 @default.
- W2011035878 cites W1998360532 @default.
- W2011035878 cites W1998499344 @default.
- W2011035878 cites W1998722012 @default.
- W2011035878 cites W1998812805 @default.
- W2011035878 cites W1998963395 @default.
- W2011035878 cites W1999857383 @default.
- W2011035878 cites W1999883312 @default.
- W2011035878 cites W2000628780 @default.
- W2011035878 cites W2001314168 @default.
- W2011035878 cites W2002550469 @default.
- W2011035878 cites W2003404396 @default.
- W2011035878 cites W2003878642 @default.
- W2011035878 cites W2004382994 @default.
- W2011035878 cites W2004954083 @default.
- W2011035878 cites W2005344677 @default.
- W2011035878 cites W2005375952 @default.
- W2011035878 cites W2005589757 @default.
- W2011035878 cites W2006796214 @default.
- W2011035878 cites W2007739626 @default.
- W2011035878 cites W2007742322 @default.
- W2011035878 cites W2008467385 @default.
- W2011035878 cites W2008833406 @default.
- W2011035878 cites W2010570838 @default.
- W2011035878 cites W2010827942 @default.
- W2011035878 cites W2012053087 @default.