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• W2011036694 abstract "The dose-response relationships and the distribution of breaks induced by irradiation were studied in phytohemagglutinin-stimulated peripheral lymphocytes from female patients treated with X-rays for cancer of the breast. The yield of dicentrics and rings was expressed by the formula y = 0.0086 + 1.53 (± 0.15) · 10−5D, and the yield of fragments by y = 0.022 + 1.68 (± 0.17) · 10−5D, where D is the accumulated skin dose in rad. The percentage of damaged cells, however, reached a plateau of 22% at about 6000 rad. In all dose ranges, the distribution of cells with various numbers of breaks deviated significantly from a Poisson distribution, which should have been obtained if all cells in the blood had been exposed to irradiation. It was possible to calculate the number of undamaged cells present in excess and, when these were omitted, a close agreement with a Poisson distribution was obtained. The results suggested that almost 30% of the circulating lymphocytes had been exposed to irradiation with the fractionated partial body procedure utilized. The effect of Newcastle disease, Sendai, measles and mumps virus infection in vitro on peripheral blood lymphocytes from irradiated patients was also studied. Virus treatment caused a decrease in the frequency of chromosome-type damage. No effect, or a slight decrease of chromatid-type damage, was seen as compared with controls treated with normal allantoic fluid." @default.
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• W2011036694 date "1970-12-01" @default.
• W2011036694 modified "2023-09-27" @default.
• W2011036694 title "Chromosome aberrations induced by X-ray therapy and myxovirus infection in human peripheral leukocytes" @default.
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• W2011036694 doi "https://doi.org/10.1016/0027-5107(70)90088-6" @default.
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