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• W2011040826 abstract "A retrospective cohort study of children with sickle cell anemia (SCA) and strokes was used to test the hypothesis that exchange transfusion at the time of stroke presentation more effectively prevents second strokes than does simple transfusion. Children receiving simple transfusion had a 5-fold greater relative risk (95% confidence interval = 1.3 to 18.6) of second stroke than those receiving exchange transfusion. A retrospective cohort study of children with sickle cell anemia (SCA) and strokes was used to test the hypothesis that exchange transfusion at the time of stroke presentation more effectively prevents second strokes than does simple transfusion. Children receiving simple transfusion had a 5-fold greater relative risk (95% confidence interval = 1.3 to 18.6) of second stroke than those receiving exchange transfusion. Questions in the management of sickle cellThe Journal of PediatricsVol. 149Issue 5PreviewCurrently, oxygen saturation by pulse oximetry (SpO2) measurements are used in well children with sickle cell disease (SCD) to provide a baseline for comparison during periods of illness. In the situation of acute illness and SpO2 lower than baseline, suspicion of an acute pulmonary process—usually acute chest syndrome (ACS)—should be high.1 In 1993, Rackoff et al1 developed a nomogram using acute measurements of SpO2 and baseline hemoglobin to derive the partial pressure of oxygen in arterial blood (PaO2) and to determine whether this value was suggestive of an acute pulmonary process. Full-Text PDF Daytime pulse oximeter measurements do not predict incidence of pain and acute chest syndrome episodes in sickle cell anemiaThe Journal of PediatricsVol. 149Issue 5PreviewA prospective, infant cohort study of children with sickle cell anemia was evaluated to determine the relationship between daytime pulse oximeter measurements and the incidence of pain and acute chest episodes (ACS). A total of 130 children were evaluated. The Pearson correlation between SpO2 and pain and ACS episode rates were 0.00 (P = .97) and 0.10 (P = .27), respectively. Daytime SpO2 cannot independently predict the subsequent rate of pain and ACS episodes. Full-Text PDF" @default.
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• W2011040826 date "2006-11-01" @default.
• W2011040826 modified "2023-10-14" @default.
• W2011040826 title "Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: A retrospective cohort study of 137 children with sickle cell anemia" @default.
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• W2011040826 doi "https://doi.org/10.1016/j.jpeds.2006.06.037" @default.
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