FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011041372> ?p ?o ?g. }

• W2011041372 endingPage "833" @default.
• W2011041372 startingPage "822" @default.
• W2011041372 abstract "Parkinson's disease (PD) is a progressive neurological disorder characterized by a selective loss of dopamine (DA) neurons in the substantia nigra (SN). Although current therapy can control symptoms of this disorder, there is no effective therapy available to halt its progression. Recently, neuroinflammation has been recognized as an important contributor to the pathogenesis of PD, and nuclear factor-kappaB (NF-kappaB) plays a key role in regulating neuroinflammation. Hence, the modulation of NF-kappaB pathway may have therapeutic potential for PD. Activation of NF-kappaB depends on the phosphorylation of its inhibitor, IkappaB, by the specific IkappaB kinase (IKK) subunit IKK-beta. Compound A (7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1, 4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride), a potent and selective inhibitor of IKK-beta, has recently been reported to provide cardioprotection through specific suppression of NF-kappaB signaling. The present study, for the first time, elucidates neuroprotective effects of compound A. Daily subcutaneous injection of compound A (1 mg/kg) for 7 days inhibited the activation of microglia induced by nigral stereotaxic injection of lipopolysaccharide (LPS) and significantly attenuated LPS-induced loss of DA neurons in the SN. In vitro mechanistic studies revealed that neuroprotective effects of compound A were mediated by 1) suppressing the activity of microglial NADPH oxidase and decreasing the production of reactive oxygen species, and 2) inhibiting NF-kappaB-mediated gene transcription of various proinflammatory mediators in microglia via IKK-beta suppression. These findings indicate that compound A afforded potent neuroprotection against LPS-induced neurodegeneration through selective inhibition of NF-kappaB activation and may be of potential benefit in the treatment of PD." @default.
• W2011041372 created "2016-06-24" @default.
• W2011041372 creator A5014942240 @default.
• W2011041372 creator A5049939869 @default.
• W2011041372 creator A5052274720 @default.
• W2011041372 creator A5056052081 @default.
• W2011041372 creator A5067094023 @default.
• W2011041372 creator A5071852918 @default.
• W2011041372 date "2010-02-26" @default.
• W2011041372 modified "2023-10-18" @default.
• W2011041372 title "Inhibition of IκB Kinase-β Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity" @default.
• W2011041372 cites W1492606093 @default.
• W2011041372 cites W1498346321 @default.
• W2011041372 cites W1694093395 @default.
• W2011041372 cites W1947838700 @default.
• W2011041372 cites W1966449387 @default.
• W2011041372 cites W1968730445 @default.
• W2011041372 cites W1969434975 @default.
• W2011041372 cites W1969999276 @default.
• W2011041372 cites W1974924674 @default.
• W2011041372 cites W1980020952 @default.
• W2011041372 cites W1991868611 @default.
• W2011041372 cites W2024803597 @default.
• W2011041372 cites W2037152904 @default.
• W2011041372 cites W2049876918 @default.
• W2011041372 cites W2059983531 @default.
• W2011041372 cites W2060603089 @default.
• W2011041372 cites W2075936537 @default.
• W2011041372 cites W2085116908 @default.
• W2011041372 cites W2086997247 @default.
• W2011041372 cites W2093832364 @default.
• W2011041372 cites W2098145015 @default.
• W2011041372 cites W2111464898 @default.
• W2011041372 cites W2112880160 @default.
• W2011041372 cites W2129242841 @default.
• W2011041372 cites W2132752670 @default.
• W2011041372 cites W2140053284 @default.
• W2011041372 cites W2146008698 @default.
• W2011041372 cites W2147313422 @default.
• W2011041372 cites W2149000466 @default.
• W2011041372 cites W2158211941 @default.
• W2011041372 cites W2164053161 @default.
• W2011041372 cites W2169749991 @default.
• W2011041372 cites W2169788168 @default.
• W2011041372 doi "https://doi.org/10.1124/jpet.110.165829" @default.
• W2011041372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2879929" @default.
• W2011041372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20190013" @default.
• W2011041372 hasPublicationYear "2010" @default.
• W2011041372 type Work @default.
• W2011041372 sameAs 2011041372 @default.
• W2011041372 citedByCount "84" @default.
• W2011041372 countsByYear W20110413722012 @default.
• W2011041372 countsByYear W20110413722013 @default.
• W2011041372 countsByYear W20110413722014 @default.
• W2011041372 countsByYear W20110413722015 @default.
• W2011041372 countsByYear W20110413722016 @default.
• W2011041372 countsByYear W20110413722017 @default.
• W2011041372 countsByYear W20110413722018 @default.
• W2011041372 countsByYear W20110413722019 @default.
• W2011041372 countsByYear W20110413722020 @default.
• W2011041372 countsByYear W20110413722021 @default.
• W2011041372 countsByYear W20110413722022 @default.
• W2011041372 countsByYear W20110413722023 @default.
• W2011041372 crossrefType "journal-article" @default.
• W2011041372 hasAuthorship W2011041372A5014942240 @default.
• W2011041372 hasAuthorship W2011041372A5049939869 @default.
• W2011041372 hasAuthorship W2011041372A5052274720 @default.
• W2011041372 hasAuthorship W2011041372A5056052081 @default.
• W2011041372 hasAuthorship W2011041372A5067094023 @default.
• W2011041372 hasAuthorship W2011041372A5071852918 @default.
• W2011041372 hasBestOaLocation W20110413722 @default.
• W2011041372 hasConcept C100175707 @default.
• W2011041372 hasConcept C126322002 @default.
• W2011041372 hasConcept C134018914 @default.
• W2011041372 hasConcept C137183658 @default.
• W2011041372 hasConcept C164027704 @default.
• W2011041372 hasConcept C178790620 @default.
• W2011041372 hasConcept C184235292 @default.
• W2011041372 hasConcept C185592680 @default.
• W2011041372 hasConcept C25498285 @default.
• W2011041372 hasConcept C2776914184 @default.
• W2011041372 hasConcept C2777209548 @default.
• W2011041372 hasConcept C2777730290 @default.
• W2011041372 hasConcept C2779491297 @default.
• W2011041372 hasConcept C2779719074 @default.
• W2011041372 hasConcept C2779830541 @default.
• W2011041372 hasConcept C2780938664 @default.
• W2011041372 hasConcept C29730261 @default.
• W2011041372 hasConcept C48349386 @default.
• W2011041372 hasConcept C513476851 @default.
• W2011041372 hasConcept C55493867 @default.
• W2011041372 hasConcept C62478195 @default.
• W2011041372 hasConcept C71924100 @default.
• W2011041372 hasConcept C87753298 @default.
• W2011041372 hasConcept C98274493 @default.
• W2011041372 hasConceptScore W2011041372C100175707 @default.
• W2011041372 hasConceptScore W2011041372C126322002 @default.
• W2011041372 hasConceptScore W2011041372C134018914 @default.

• next