FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011041618> ?p ?o ?g. }

• W2011041618 endingPage "290" @default.
• W2011041618 startingPage "281" @default.
• W2011041618 abstract "The endogenous polyamines spermine, spermidine and putrescine are present at high concentrations inside neurons and can be released into the extracellular space where they have been shown to modulate ion channels. Here, we have examined polyamine modulation of voltage-activated Ca2+ channels (VACCs) and voltage-activated Na+ channels (VANCs) in rat superior cervical ganglion neurons using whole-cell voltage-clamp at physiological divalent concentrations. Polyamines inhibited VACCs in a concentration-dependent manner with IC50s for spermine, spermidine, and putrescine of 4.7 ± 0.7, 11.2 ± 1.4, and 90 ± 36 mM, respectively. Polyamines caused inhibition by shifting the VACC half-activation voltage (V0.5) to depolarized potentials and by reducing total VACC permeability. The shift was described by Gouy-Chapman-Stern theory with a surface charge density of 0.120 ± 0.005 e- nm-2 and a surface potential of -19 mV. Attenuation of spermidine and spermine inhibition of VACC at decreased pH was explained by H+ titration of surface charge. Polyamine-mediated effects also decreased at elevated pH due to the inhibitors having lower valence and being less effective at screening surface charge. Polyamines affected VANC currents indirectly by reducing TTX inhibition of VANCs at high pH. This may reflect surface charge induced decreases in the local TTX concentration or polyamine-TTX interactions. In conclusion, polyamines inhibit neuronal VACCs via complex interactions with extracellular H+ and Ca. Many of the observed effects can be explained by a model incorporating polyamine binding, H+ binding and surface charge screening." @default.
• W2011041618 created "2016-06-24" @default.
• W2011041618 creator A5016724922 @default.
• W2011041618 creator A5052067649 @default.
• W2011041618 creator A5077051203 @default.
• W2011041618 date "2007-07-09" @default.
• W2011041618 modified "2023-09-23" @default.
• W2011041618 title "Modulation of Neuronal Voltage-Activated Calcium and Sodium Channels by Polyamines and pH" @default.
• W2011041618 cites W1537385836 @default.
• W2011041618 cites W1564290391 @default.
• W2011041618 cites W1867012516 @default.
• W2011041618 cites W1946405761 @default.
• W2011041618 cites W1987944310 @default.
• W2011041618 cites W1998655257 @default.
• W2011041618 cites W2001974484 @default.
• W2011041618 cites W2006356077 @default.
• W2011041618 cites W2008198581 @default.
• W2011041618 cites W2011244895 @default.
• W2011041618 cites W2017506356 @default.
• W2011041618 cites W2018345928 @default.
• W2011041618 cites W2020931572 @default.
• W2011041618 cites W2023130009 @default.
• W2011041618 cites W2025836700 @default.
• W2011041618 cites W2028274352 @default.
• W2011041618 cites W2030740718 @default.
• W2011041618 cites W2034809433 @default.
• W2011041618 cites W2036393894 @default.
• W2011041618 cites W2042609891 @default.
• W2011041618 cites W2042740631 @default.
• W2011041618 cites W2055252729 @default.
• W2011041618 cites W2056422818 @default.
• W2011041618 cites W2057842052 @default.
• W2011041618 cites W2064379457 @default.
• W2011041618 cites W2067239852 @default.
• W2011041618 cites W2068521925 @default.
• W2011041618 cites W2068662199 @default.
• W2011041618 cites W2069440400 @default.
• W2011041618 cites W2080983994 @default.
• W2011041618 cites W2083033319 @default.
• W2011041618 cites W2085556002 @default.
• W2011041618 cites W2086012640 @default.
• W2011041618 cites W2093660899 @default.
• W2011041618 cites W2100912112 @default.
• W2011041618 cites W2104592058 @default.
• W2011041618 cites W2105952145 @default.
• W2011041618 cites W2110095865 @default.
• W2011041618 cites W2111282444 @default.
• W2011041618 cites W2118938877 @default.
• W2011041618 cites W2123369785 @default.
• W2011041618 cites W2123521142 @default.
• W2011041618 cites W2135440354 @default.
• W2011041618 cites W2148011337 @default.
• W2011041618 cites W2155115919 @default.
• W2011041618 cites W2155538402 @default.
• W2011041618 cites W2402387561 @default.
• W2011041618 cites W2414888077 @default.
• W2011041618 cites W2436948428 @default.
• W2011041618 doi "https://doi.org/10.4161/chan.4988" @default.
• W2011041618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2561315" @default.
• W2011041618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18708745" @default.
• W2011041618 hasPublicationYear "2007" @default.
• W2011041618 type Work @default.
• W2011041618 sameAs 2011041618 @default.
• W2011041618 citedByCount "14" @default.
• W2011041618 countsByYear W20110416182012 @default.
• W2011041618 countsByYear W20110416182016 @default.
• W2011041618 countsByYear W20110416182019 @default.
• W2011041618 countsByYear W20110416182022 @default.
• W2011041618 countsByYear W20110416182023 @default.
• W2011041618 crossrefType "journal-article" @default.
• W2011041618 hasAuthorship W2011041618A5016724922 @default.
• W2011041618 hasAuthorship W2011041618A5052067649 @default.
• W2011041618 hasAuthorship W2011041618A5077051203 @default.
• W2011041618 hasBestOaLocation W20110416181 @default.
• W2011041618 hasConcept C12554922 @default.
• W2011041618 hasConcept C147789679 @default.
• W2011041618 hasConcept C178790620 @default.
• W2011041618 hasConcept C181199279 @default.
• W2011041618 hasConcept C185592680 @default.
• W2011041618 hasConcept C2776109719 @default.
• W2011041618 hasConcept C2777167505 @default.
• W2011041618 hasConcept C2777497464 @default.
• W2011041618 hasConcept C2780115381 @default.
• W2011041618 hasConcept C2780358262 @default.
• W2011041618 hasConcept C28406088 @default.
• W2011041618 hasConcept C4141045 @default.
• W2011041618 hasConcept C55493867 @default.
• W2011041618 hasConcept C74884574 @default.
• W2011041618 hasConcept C86803240 @default.
• W2011041618 hasConceptScore W2011041618C12554922 @default.
• W2011041618 hasConceptScore W2011041618C147789679 @default.
• W2011041618 hasConceptScore W2011041618C178790620 @default.
• W2011041618 hasConceptScore W2011041618C181199279 @default.
• W2011041618 hasConceptScore W2011041618C185592680 @default.
• W2011041618 hasConceptScore W2011041618C2776109719 @default.
• W2011041618 hasConceptScore W2011041618C2777167505 @default.
• W2011041618 hasConceptScore W2011041618C2777497464 @default.
• W2011041618 hasConceptScore W2011041618C2780115381 @default.

• next